Nagarajan Aswin, Ravichandar Ramya
Department of Radiation Oncology, Cancer Institute (WIA), Chennai, Tamil Nadu, India.
Department of Pharmacology, Sree Balaji Medical College and Hospital, Chennai, Tamil Nadu, India.
J Clin Transl Res. 2021 Nov 29;7(6):792-796. eCollection 2021 Dec 28.
Primary spinal cord glioblastoma multiforme (GBM) is a rare clinical condition and is often associated with a dismal prognosis. The standard treatment is maximal safe surgery followed by adjuvant radiotherapy and chemotherapy. Despite such aggressive treatments, the median survival is estimated to be around 15 months in several studies. We report three patients with primary spinal GBM who received treatment in our institute from 2012 to 2019. Among the three, one patient is on long-term follow-up with no evidence of disease, another patient succumbed to the illness and the third patient is having stable disease.
Although primary spinal GBM is usually associated with a dismal prognosis, our case series shows a subset of patients will have a favorable outcome with the protocol treatment.
原发性脊髓多形性胶质母细胞瘤（GBM）是一种罕见的临床病症，通常预后不佳。标准治疗方法是进行最大程度的安全手术，随后进行辅助放疗和化疗。尽管采取了如此积极的治疗措施，但多项研究估计中位生存期约为15个月。我们报告了2012年至2019年在我院接受治疗的3例原发性脊髓GBM患者。其中，1例患者正在接受长期随访，无疾病证据，另1例患者因病死亡，第3例患者病情稳定。
尽管原发性脊髓GBM通常预后不佳，但我们的病例系列显示，一部分患者通过方案治疗将获得良好的结果。
