Cruz-Lim Ella Mae, Germain François, Sauciuc Delia, Mou Benjamin
Department of Radiation Oncology, BC Cancer Agency Sindi Ahluwalia Hawkins Centre for the Southern Interior, Kelowna, CAN.
Department of Radiation Oncology, Zamboanga City Medical Center, Zamboanga City, PHL.
Cureus. 2022 Dec 6;14(12):e32272. doi: 10.7759/cureus.32272. eCollection 2022 Dec.
Primary spinal glioblastoma (GBM) is a rare disease entity with no established standard treatment. We present two cases of primary spinal GBM initially presenting with motor-sensory deficits and back pain. Management varied in that the first patient received subtotal resection followed by radiation therapy, while the second patient underwent gross total resection followed by radiation therapy and temozolomide. The first patient died from hypoxemia secondary to disease progression affecting diaphragmatic motion three months after diagnosis. The second patient progressed intracranially and died 7.4 months after diagnosis. There is no standard of care for primary spinal GBM, so treatment should follow a multidisciplinary discussion focused on patient-specific goals. These cases highlight the poor prognosis of primary spinal GBM despite different treatment approaches, necessitating accurate reporting of all similar cases to help improve knowledge and management of this rare malignancy.
原发性脊髓胶质母细胞瘤（GBM）是一种罕见的疾病实体，尚无既定的标准治疗方法。我们报告两例原发性脊髓GBM病例，最初表现为运动感觉障碍和背痛。治疗方法有所不同，第一例患者接受了次全切除，随后进行放射治疗，而第二例患者接受了全切除，随后进行放射治疗和替莫唑胺治疗。第一例患者在诊断后三个月因疾病进展影响膈肌运动继发低氧血症死亡。第二例患者颅内病情进展，在诊断后7.4个月死亡。原发性脊髓GBM尚无标准的治疗方案，因此治疗应遵循以患者特定目标为重点的多学科讨论。这些病例突出了原发性脊髓GBM尽管治疗方法不同但预后较差的情况，有必要准确报告所有类似病例，以帮助提高对这种罕见恶性肿瘤的认识和管理水平。
