Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China.
J Magn Reson Imaging. 2022 Aug;56(2):508-515. doi: 10.1002/jmri.28043. Epub 2022 Jan 5.
Hypertension (HTN) might impair cognition. Brain iron deposition correlates with cognitive impairment. The relationship between brain iron and cognition in HTN patients is less clear.
To measure brain susceptibility in HTN patients using quantitative susceptibility mapping (QSM) and to explore the relationship between brain iron and cognition.
Retrospective cross-sectional study.
Sixty HTN patients (35 with mild cognitive impairment [MCI] and 25 without MCI) and 24 age, gender, and education matched controls.
FIELD STRENGTH/SEQUENCE: 3 T; strategically acquired gradient echo (STAGE) imaging protocol for QSM analysis.
All subjects underwent Montreal Cognitive Assessment (MoCA) scoring of visuospatial/executive, naming, attention, abstraction, language, delayed memory, and orientation functions. HTN patients were divided into two groups (with and without MCI) depending on the MoCA score. Regions of interest (ROIs) were manually demarcated on the STAGE images by three independent radiologists and susceptibility were determined for bilateral frontal white matter, parietal white matter, occipital white matter, caudate nucleus (CN), putamen (PU), globus pallidus (GP), thalamus (TH), red nucleus (RN), substantia nigra (SN), and dentate nucleus (DN).
Analysis of variance with post-hoc least significant difference (LSD) tests and Pearson correlation coefficients (r). A P-value <0.05 was considered to be statistically significant.
The susceptibility was significantly different in CN, PU, and DN among the three groups. The susceptibility of right CN and left PU were correlated with MoCA scores (r = -0.429 and r = -0.389, respectively). The susceptibility of left PU was also correlated with delayed memory scores (r = -0.664). The susceptibility of left and right GP were correlated with naming scores (r = -0.494 and r = -0.446, respectively) and the susceptibility of left DN were correlated with visuospatial/executive scores (r = 0.479).
QSM measured brain iron was significantly higher in CN, PU, and DN in HTN patients. Cognitive impairment was correlated with regional brain iron deposition.
2 TECHNICAL EFFICACY: Stage 3.
高血压（HTN）可能会损害认知能力。脑铁沉积与认知障碍相关。HTN 患者的脑铁与认知之间的关系尚不清楚。
使用定量磁化率映射（QSM）测量 HTN 患者的脑磁化率，并探讨脑铁与认知之间的关系。
回顾性横断面研究。
60 名 HTN 患者（35 名伴轻度认知障碍 [MCI]，25 名无 MCI）和 24 名年龄、性别和教育程度匹配的对照者。
磁场强度/序列：3T；用于 QSM 分析的策略性获取梯度回波（STAGE）成像方案。
所有受试者均接受蒙特利尔认知评估（MoCA）评分，评估视空间/执行、命名、注意力、抽象、语言、延迟记忆和定向功能。根据 MoCA 评分，HTN 患者分为两组（有和无 MCI）。由三位独立的放射科医生手动在 STAGE 图像上勾画感兴趣区（ROI），并确定双侧额叶白质、顶叶白质、枕叶白质、尾状核（CN）、壳核（PU）、苍白球（GP）、丘脑（TH）、红核（RN）、黑质（SN）和齿状核（DN）的磁化率。
方差分析，事后最小显著差异（LSD）检验和 Pearson 相关系数（r）。P 值<0.05 被认为具有统计学意义。
三组之间 CN、PU 和 DN 的磁化率存在显著差异。右侧 CN 和左侧 PU 的磁化率与 MoCA 评分相关（r=-0.429 和 r=-0.389）。左侧 PU 的磁化率也与延迟记忆评分相关（r=-0.664）。左、右 GP 的磁化率与命名评分相关（r=-0.494 和 r=-0.446），左 DN 的磁化率与视空间/执行评分相关（r=0.479）。
QSM 测量的 HTN 患者脑铁在 CN、PU 和 DN 中显著升高。认知障碍与脑内局部铁沉积相关。
2 级技术功效：3 级。
