Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, China.
Department of Endocrinology, The Second Affiliated Hospital of Kunming Medical University, Kunming, China.
J Diabetes. 2022 Jan;14(1):64-72. doi: 10.1111/1753-0407.13242.
Atherosclerosis is a common complication in patients with type 2 diabetes (T2DM). Multiple factors are involved in the development and progress of atherosclerosis. We evaluated the association of weekly sedentary time (WST) with carotid plaque formation.
After data cleaning, a total of 26 664 participants with T2DM from 10 National Metabolic Management Centers (MMCs) from June 2017 to April 2021 were enrolled. Self-reported lifestyle data including WST, sleeping time, smoking and drinking information, carotid artery ultrasound, and biochemical parameters were obtained. The independent association of carotid plaue with sedentary and other lifestyle behaviors was evaluated using multivariable logistic regression models, and odds ratio (OR) with 95% confidence interval (CI) were reported. Moreover, stratified analysis was conducted to demonstrate the influence of confounding factors.
The mean (SD) age of the participants was 54.0 (11.6) years, and the median (interquartile range) WST was 35.0 (21.0, 42.0) h. Comparing with participants in the first tertile of WST, those in the second or third tertile of WST were younger and with a shorter duration of diabetes. There were positive associations between longer sedentary time and odds of artery plaque after adjustment, with corresponding ORs in the second and third tertile were 1.40 (95% CI: 1.31-1.50) and 1.67 (95% CI: 1.56-1.79), respectively. However, the effect of WST on plaque in patients aged 18-40 years old had no statistical significance; the p value in the third tertile was 0.163.
In summary, higher WST appears to be associated with higher prevalence of carotid plaque in patients with T2DM, especially in aged populations.
动脉粥样硬化是 2 型糖尿病（T2DM）患者常见的并发症。多种因素参与了动脉粥样硬化的发生和进展。我们评估了每周久坐时间（WST）与颈动脉斑块形成的关系。
在数据清理后，我们共纳入了来自 2017 年 6 月至 2021 年 4 月 10 个国家代谢管理中心（MMC）的 26664 例 T2DM 患者。收集了包括 WST、睡眠时间、吸烟和饮酒信息、颈动脉超声和生化参数在内的生活方式数据。采用多变量逻辑回归模型评估颈动脉斑块与久坐和其他生活方式行为的独立相关性，并报告比值比（OR）及其 95%置信区间（CI）。此外，还进行了分层分析以显示混杂因素的影响。
参与者的平均（SD）年龄为 54.0（11.6）岁，中位（四分位距）WST 为 35.0（21.0，42.0）h。与 WST 处于第 1 个三分位数的参与者相比，WST 处于第 2 或第 3 个三分位的参与者更年轻，且糖尿病病程更短。在调整后，较长的久坐时间与动脉斑块的发生呈正相关，WST 处于第 2 和第 3 个三分位的相应 OR 分别为 1.40（95%CI：1.31-1.50）和 1.67（95%CI：1.56-1.79）。然而，WST 对 18-40 岁患者斑块的影响没有统计学意义；第 3 个三分位的 p 值为 0.163。
总之，较高的 WST 似乎与 T2DM 患者颈动脉斑块的发生率升高有关，尤其是在老年人群中。
