Drew J P, Westrum L E, Baskin D B, Franck J E
Department of Neurological Surgery, University of Washington, Seattle 98195.
Neurosci Lett. 1987 Sep 11;80(1):39-43. doi: 10.1016/0304-3940(87)90491-5.
Benzodiazepine (BZ) binding is being studied in the spinal trigeminal nucleus of the cat 3 and 11 days following unilateral retrogasserian rhizotomy using in vitro autoradiography and computer-assisted densitometry. At 3 days following rhizotomy there is an increase in number and decrease in affinity of flunitrazepam binding sites in the superficial laminae of subnucleus caudalis of the spinal trigeminal complex. By 11 days, affinity remains below control values and binding site number shows an insignificant but detectable increase. There is no change in binding site characteristics in deeper laminae at either survival time. The results are discussed in relation to the physiological hyperactivity and synaptic changes which occur following such lesions and to other conditions of deafferentation.
在单侧半月节后根切断术后3天和11天，利用体外放射自显影和计算机辅助密度测定法，对猫的三叉神经脊束核中的苯二氮䓬（BZ）结合情况进行了研究。在根切断术后3天，三叉神经脊束复合体尾侧亚核浅层中氟硝西泮结合位点的数量增加，亲和力降低。到11天时，亲和力仍低于对照值，结合位点数量虽有不显著但可检测到的增加。在任一存活时间，深层的结合位点特征均无变化。结合此类损伤后发生的生理功能亢进和突触变化以及其他去传入状态，对结果进行了讨论。
