Department of Gynecologic Oncology, University of Health Sciences, Bakirkoy Dr Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
Department of Gynecologic Oncology, Istanbul Medipol University, Istanbul, Turkey.
Nutr Cancer. 2022;74(5):1770-1779. doi: 10.1080/01635581.2021.2022170. Epub 2022 Jan 6.
This study aimed to investigate the association between preoperative prognostic nutritional index (PNI) and controlling nutritional status (CONUT) scores on the stage of ovarian cancer (OC), chemotherapeutic response, and overall survival (OS) in patients with OC. The data of the patients who operated due to OC between January 2015 and January 2020 in a tertiary referral hospital were recorded. The patients' basic characteristics, preoperative total cholesterol, albumin, lymphocyte count, tumor markers, disease stage, grade, chemotherapeutic response, OS, and progression-free survival were recorded. The PNI and the CONUT score were calculated. The mean PNI level was considerably higher in the early-stage group than the advanced-stage group (50.02 ± 6.8 vs. 46.3 ± 7.4, = 0.005). The AUC was 63% for the cutoff point 45.98 of PNI, whereas the AUC was 42% for the cutoff point 1.5 of CONUT score in predicting early-stage disease. The PFS and OS were significantly higher in the high PNI group than the low PNI group ( = 0.01, = 0.002, respectively). The patients with early-stage OC had significantly higher PNI levels and lower CONUT scores in our study population.
本研究旨在探讨术前预后营养指数（PNI）和控制营养状况（CONUT）评分与卵巢癌（OC）分期、化疗反应和总生存期（OS）的关系。记录了 2015 年 1 月至 2020 年 1 月在一家三级转诊医院因 OC 接受手术的患者的数据。记录了患者的基本特征、术前总胆固醇、白蛋白、淋巴细胞计数、肿瘤标志物、疾病分期、分级、化疗反应、OS 和无进展生存期。计算了 PNI 和 CONUT 评分。早期组的平均 PNI 水平明显高于晚期组（50.02 ± 6.8 vs. 46.3 ± 7.4，= 0.005）。PNI 截断值为 45.98 时，AUC 为 63%，而 CONUT 评分截断值为 1.5 时，AUC 为 42%，用于预测早期疾病。高 PNI 组的 PFS 和 OS 明显高于低 PNI 组（= 0.01，= 0.002）。在我们的研究人群中，早期 OC 患者的 PNI 水平明显较高，CONUT 评分较低。
