Konturek S J, Yanaihara C, Yanaihara N, Mochizuki T, Bilski J, Dembinski A, Jaworek J
Institute of Physiology, Academy of Medicine, Krakow, Poland.
Peptides. 1987 May-Jun;8(3):575-7. doi: 10.1016/0196-9781(87)90026-x.
Human CRF given IV inhibited dose-dependently pentagastrin- but not histamine-induced gastric acid secretion. When added to the incubation medium of the isolated gastric glands, CRF did not alter the formation of HCl under basal conditions or after stimulation with histamine or DBcAMP. CRF caused a small but significant increase in pancreatic HCO3 and protein secretion. It augmented CCK-induced pancreatic protein and secretin-induced HCO3 secretion in vivo but failed to affect basal or stimulated (CCK and urecholine) amylase release by the in vitro dispersed pancreatic acini. This study indicates that CRF inhibits gastric and stimulates pancreatic secretion in vivo but not in vitro and these effects are indirect involving, at least in part, alterations in the pancreatic circulation.
静脉注射人促肾上腺皮质激素释放因子（CRF）可剂量依赖性地抑制五肽胃泌素诱导的胃酸分泌，但不影响组胺诱导的胃酸分泌。当添加到分离的胃腺孵育培养基中时，CRF在基础条件下或在组胺或二丁酰环磷腺苷（DBcAMP）刺激后不会改变盐酸的形成。CRF使胰腺碳酸氢盐和蛋白质分泌略有但显著增加。它在体内增强了胆囊收缩素（CCK）诱导的胰腺蛋白质分泌和促胰液素诱导的碳酸氢盐分泌，但未能影响体外分散的胰腺腺泡基础或刺激（CCK和乌拉胆碱）淀粉酶的释放。这项研究表明，CRF在体内抑制胃分泌并刺激胰腺分泌，但在体外则不然，这些作用是间接的，至少部分涉及胰腺循环的改变。
