Konturek S J, Bilski J, Pawlik W, Thor P, Czarnobilski K, Szoke B, Schally A V
Life Sci. 1985 Sep 30;37(13):1231-40. doi: 10.1016/0024-3205(85)90135-3.
This study was designed to determine the effects of CRF on the gastrointestinal functions such as secretion, motility and circulation in dogs. CRF was found to inhibit dose-dependently gastric acid response to pentagastrin but not to histamine. CRF stimulated pancreatic bicarbonate and protein secretion under basal conditions and in response to secretin or cholecystokinin (CCK). This stimulation was accompanied by an increase in plasma levels of pancreatic polypeptide (PP), but not of secretin or gastrin. CRF caused a partial inhibition of the migrating motor complexes in fasted dogs and increased spike activity of the small bowel. These motor effects of CRF probably resulted from the action of the released PP on the intestinal smooth muscle. CRF is also a potent and selective stimulant of the mesenteric blood flow. This effect may be secondary to the stimulation of intestinal motility and metabolism.
本研究旨在确定促肾上腺皮质激素释放因子（CRF）对犬胃肠道功能（如分泌、运动和循环）的影响。发现CRF能剂量依赖性地抑制对五肽胃泌素的胃酸反应，但对组胺无此作用。在基础状态下以及对促胰液素或胆囊收缩素（CCK）的反应中，CRF刺激胰腺碳酸氢盐和蛋白质分泌。这种刺激伴随着血浆中胰多肽（PP）水平的升高，但促胰液素或胃泌素水平未升高。CRF对禁食犬的移行性运动复合波有部分抑制作用，并增加小肠的锋电位活动。CRF的这些运动效应可能是释放的PP对肠平滑肌作用的结果。CRF也是肠系膜血流的一种强效且选择性的刺激物。这种效应可能继发于对肠道运动和代谢的刺激。
