通过单克隆抗体检测到人类T细胞慢性淋巴细胞白血病（T-CLL）上的三种肿瘤特异性表面分子。

Three kinds of tumour-unique surface molecules on a human T-cell chronic lymphocytic leukaemia (T-CLL) detected by monoclonal antibodies.

作者信息

Janson C H, Jeddi Tehrani M, Mellstedt H, Wigzell H

机构信息

Department of Immunology, Karolinska Institute, Stockholm, Sweden.

出版信息

Scand J Immunol. 1987 Sep;26(3):237-46. doi: 10.1111/j.1365-3083.1987.tb02257.x.

DOI:10.1111/j.1365-3083.1987.tb02257.x

PMID:3498981

Abstract

Mouse monoclonal antibodies recognizing cell surface molecules on tumour cells from a patient with a T-cell chronic lymphatic leukaemia (T-CLL) have been produced. Three different types of idiotype-like cell surface structures were identified. One molecule had a relative molecular weight (Mr) of 90,000 under non-reduced conditions and of 42,000 upon reduction, which corresponds well to the T-cell receptor for antigen (Ti). The two other molecules, which also behaved like unique tumour markers, have not previously been described, to our knowledge. One molecule was a monomer with an Mr of 74,000-80,000 when non-reduced and 80,000 upon reduction. The other idiotypic molecule was a dimer with a non-reduced Mr of 74,000-80,000, and 38,000 after reduction.

摘要

已制备出识别一名T细胞慢性淋巴细胞白血病（T-CLL）患者肿瘤细胞表面分子的小鼠单克隆抗体。鉴定出三种不同类型的独特型样细胞表面结构。一种分子在非还原条件下相对分子质量（Mr）为90,000，还原后为42,000，这与抗原T细胞受体（Ti）非常相符。据我们所知，另外两种分子也表现为独特的肿瘤标志物，此前尚未见报道。一种分子为单体，非还原时Mr为74,000 - 80,000，还原后为80,000。另一种独特型分子为二聚体，非还原时Mr为74,000 - 80,000，还原后为38,000。