Kilpatrick D C, Liston W A, Jazwinska E C, Smart G E
Blood Transfusion Centre, Royal Infirmary, Edinburgh, Scotland.
Tissue Antigens. 1987 May;29(5):232-6. doi: 10.1111/j.1399-0039.1987.tb01582.x.
Full HLA-A, B and DR types were obtained for 22 families (mothers, fathers and neonates) associated with severe (proteinuric) pre-eclampsia, 21 families associated with mild pre-eclampsia, and 132 families associated with normal pregnancies. There was an increased frequency of DR4 (relative risk 3.6: p less than 0.003, uncorrected) in both neonates and mothers of the severe pre-eclampsia families when compared to the normotensive controls. There were no significant differences between either pre-eclampsia group and controls in HLA antigen homozygosity, HLA antigen sharing or in lymphocytotoxin production.
对22个与重度（蛋白尿性）先兆子痫相关的家庭（母亲、父亲和新生儿）、21个与轻度先兆子痫相关的家庭以及132个与正常妊娠相关的家庭进行了完整的HLA - A、B和DR分型。与血压正常的对照组相比，重度先兆子痫家庭的新生儿和母亲中DR4的频率增加（相对风险3.6：p小于0.003，未校正）。在HLA抗原纯合性、HLA抗原共享或淋巴细胞毒素产生方面，先兆子痫组与对照组之间均无显著差异。
