Department of Radiology, Gifu University, Gifu, Japan.
Department of Dermatology, Gifu University, Gifu, Japan.
Br J Radiol. 2022 Apr 1;95(1132):20211003. doi: 10.1259/bjr.20211003. Epub 2022 Jan 7.
This study aimed to evaluate the prognostic value of F-fludeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) and MRI features in patients with high-risk and very-high-risk cutaneous squamous cell carcinoma (cSCC).
This study included 54 consecutive patients with surgically resected primary high-risk and very-high-risk cSCC who underwent pre-operative FDG-PET/CT and/or MRI. Among them, 14 patients (26%) had recurrences. We retrospectively reviewed the FDG-PET/CT ( = 34) and MRI ( = 48) and investigated the clinical significance and prognostic value of imaging features in cSCC.
On FDG-PET/CT, the maximum standardized uptake value (SUVmax) of the primary tumor (13.0 ± 6.4 vs. 6.9 ± 5.3, < 0.05) was higher in cSCC with recurrence than in cSCC without recurrence. On MRI, the maximum diameter of the lesion (46.8 ± 24.1 mm 30.4 ± 17.0 mm, < 0.05) and the frequency of muscle/tendon/bone invasion (42% 11%, < 0.05) were significantly greater in cSCC with recurrence than in cSCC without recurrence. In the univariate analysis, prognostic factors for recurrence were SUVmax of the primary tumor ( < 0.01), the maximum diameter of the lesion ( < 0.05), and depth of invasion ( < 0.05). The areas under the receiver operating characteristic curves of the SUVmax (0.78) were superior to those of the maximum diameter (0.71) and depth of invasion (0.60).
SUVmax, maximum diameter, and depth of invasion were useful parameters for prognostic factors predicting recurrence in patients with high-risk and very-high-risk cSCC.
SUVmax represents a prognostic factor.
本研究旨在评估氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（FDG-PET/CT）和磁共振成像（MRI）特征在高危和极高危皮肤鳞状细胞癌（cSCC）患者中的预后价值。
本研究纳入了 54 例接受手术切除的原发性高危和极高危 cSCC 患者，这些患者均进行了术前 FDG-PET/CT 和/或 MRI 检查。其中 14 例（26%）患者发生了复发。我们回顾性分析了 FDG-PET/CT（=34 例）和 MRI（=48 例），并研究了 cSCC 中影像学特征的临床意义和预后价值。
在 FDG-PET/CT 上，复发的 cSCC 原发肿瘤的最大标准化摄取值（SUVmax）（13.0±6.4 比 6.9±5.3， <0.05）高于无复发的 cSCC。在 MRI 上，复发的 cSCC 的病变最大直径（46.8±24.1mm 比 30.4±17.0mm， <0.05）和肌肉/肌腱/骨骼侵犯的频率（42%比 11%， <0.05）明显高于无复发的 cSCC。单因素分析显示，肿瘤 SUVmax（ <0.01）、病变最大直径（ <0.05）和浸润深度（ <0.05）是复发的预后因素。SUVmax 的受试者工作特征曲线下面积（0.78）优于病变最大直径（0.71）和浸润深度（0.60）。
SUVmax、最大直径和浸润深度是预测高危和极高危 cSCC 患者复发的预后因素。
SUVmax 是一个预后因素。
