Department of Biotechnology, College of Science and Humanities, SRM Institute of Science and Technology, Kattankulathur, Chennai 603 203, Tamil Nadu, India.
International Institute of Aquaculture and Aquatic Sciences (I-AQUAS), Universiti Putra Malaysia, 71050 Port Dickson, Negeri Sembilan, Malaysia.
Life Sci. 2022 Feb 15;291:120276. doi: 10.1016/j.lfs.2021.120276. Epub 2022 Jan 3.
Polycystic ovarian syndrome (PCOS) causes swollen ovaries in women at reproductive age due to hormonal disorder with small cysts on the outer edges. The cause of the disorder is still yet to be found. Multiple factors have increased PCOS prevalence, hyperandrogenism, oxidative stress, inflammation, and insulin resistance. Various animal PCOS models have been developed to imitate the pathophysiology of PCOS in humans. Zebrafish is one of the most versatile animal experimental models because of the transparency of the embryos, small size, and rapid growth. The zebrafish similarity to higher vertebrates made it a useful non-mammalian model for PCOS drug testing and screening. This review provides an insight into the usage of zebrafish, a non-mammalian model for PCOS, as an opportunity for evaluating future initiatives in such a research domain.
多囊卵巢综合征（PCOS）是一种生殖年龄妇女的荷尔蒙失调疾病，其特征是卵巢肿胀，边缘有小囊肿。该疾病的病因尚未确定。多种因素导致 PCOS 患病率增加，如高雄激素血症、氧化应激、炎症和胰岛素抵抗。已经开发出多种动物 PCOS 模型来模拟人类 PCOS 的病理生理学。斑马鱼是最通用的动物实验模型之一，因为其胚胎透明、体型小且生长迅速。斑马鱼与高等脊椎动物的相似性使其成为 PCOS 药物测试和筛选的有用非哺乳动物模型。本综述探讨了将斑马鱼作为 PCOS 的非哺乳动物模型的应用，为该研究领域的未来计划提供了一个机会。
