Zha Wenwen, Hu Weitao, Ge Chenkai, Chen Jianjun, Cao Zigang
Jiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases, Jiangxi Key Laboratory of Developmental Biology of Organs and Epigenetics, College of Chinese Medicine, Clinical Research Center of Affiliated Hospital of Jinggangshan University, Jinggangshan University, Ji'an, China.
Jiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases, Jiangxi Key Laboratory of Organs Development and Epigenetics, Key Laboratory of Jiangxi Province for Biological Invasion and Biosecurity, College of Life Sciences, Clinical Research Center of Affiliated Hospital of Jinggangshan University, Jinggangshan University, Ji'an, China.
Front Cell Dev Biol. 2024 Dec 23;12:1481634. doi: 10.3389/fcell.2024.1481634. eCollection 2024.
Reproductive system diseases have become a major health challenge facing humans, so extensive investigations are needed to understand their complex pathogenesis and summarize effective treatments. In the study of reproductive diseases, mice are the most commonly used animal model. However, the cost and time required to establish mouse animal models are high. The existing zebrafish model can solve this problem well. Zebrafish is an animal model with great application prospects and has lots of advantages, including high degree of genetic conservation with humans, short reproductive cycle, transparent embryos, and rapid growth, providing unique opportunities for high-throughput drug screening and identification of potential treatments. Researchers have successfully used chemical induction, physical damage, gene editing technology, etc., to induce reproductive system damage in zebrafish to study the biological processes related to its reproductive diseases. Therefore, in this review, the main models and related advantages of zebrafish in reproductive diseases are summarized, the pathological mechanisms of zebrafish as a reproductive disease model are clarified, and new perspectives and valuable insights are provided for the treatment of human reproductive diseases. The literature and data cited in the review are all from PubMed, covering important research results on zebrafish reproductive diseases in the past 10 years.
生殖系统疾病已成为人类面临的一项重大健康挑战，因此需要进行广泛的研究以了解其复杂的发病机制并总结有效的治疗方法。在生殖疾病的研究中，小鼠是最常用的动物模型。然而，建立小鼠动物模型所需的成本和时间很高。现有的斑马鱼模型可以很好地解决这个问题。斑马鱼是一种具有巨大应用前景的动物模型，具有许多优点，包括与人类的遗传保守度高、生殖周期短、胚胎透明以及生长迅速，为高通量药物筛选和潜在治疗方法的鉴定提供了独特的机会。研究人员已成功使用化学诱导、物理损伤、基因编辑技术等在斑马鱼中诱导生殖系统损伤，以研究与其生殖疾病相关的生物学过程。因此，在本综述中，总结了斑马鱼在生殖疾病中的主要模型及相关优势，阐明了斑马鱼作为生殖疾病模型的病理机制，并为人类生殖疾病的治疗提供了新的视角和有价值的见解。综述中引用的文献和数据均来自PubMed，涵盖了过去10年中关于斑马鱼生殖疾病的重要研究成果。
