Manjili Masoud H, Khazaie Khashayarsha
Department of Microbiology & Immunology, VCU School of Medicine, Massey Cancer Center, 401 College Street, Box 980035, Richmond, VA, 23298, United States.
Department of Internal Medicine, Mayo Clinic, Phoenix, AZ, United States.
Semin Cancer Biol. 2022 Jan;78:1-4. doi: 10.1016/j.semcancer.2021.12.008. Epub 2022 Jan 3.
In this thematic issue, several mechanisms of tumor dormancy and relapse are discussed. The reviews suggest mutual interactions and communications between malignant cells and other cells in their niche during tumor dormancy. Nevertheless, a complete understanding of tumor dormancy remains elusive. This is because we are getting lost in details of cell-intrinsic and cell-extrinsic molecular pathways without being able to discover the pattern of tumor dormancy. Here, we discuss some conceptual frameworks and methodological approaches that facilitate pattern recognition of tumor dormancy, and propose that settling on certain biological scale such as mitochondria would be the key to discover the pattern of tumor dormancy and relapse.
在本期专题中，讨论了肿瘤休眠和复发的几种机制。这些综述表明，在肿瘤休眠期间，恶性细胞与其微环境中的其他细胞之间存在相互作用和通讯。然而，对肿瘤休眠的全面理解仍然难以捉摸。这是因为我们迷失在细胞内在和细胞外在分子途径的细节中，无法发现肿瘤休眠的模式。在这里，我们讨论了一些有助于识别肿瘤休眠模式的概念框架和方法，并提出确定某些生物学尺度，如线粒体，将是发现肿瘤休眠和复发模式的关键。
