Moran K T, O'Reilly T J, Allo M, Munster A M
Department of Surgery, Johns Hopkins University School of Medicine, Maryland.
Burns Incl Therm Inj. 1987 Aug;13(4):266-8. doi: 10.1016/0305-4179(87)90043-x.
Following thermal injury, anaphylotoxins (C3a and C5a) are generated by complement activity. We measured C3a and C5a levels serially in 18 seriously burned patients (mean burn size = 37.9 per cent body surface area) over the initial 3 weeks following injury. Values for C3a were significantly increased when compared with normal controls, with maximum levels during the second week, while C5a levels were slightly elevated initially. These levels did not correlate with the extent of tissue injury, the development of septic complications or the clinical outcome. However, it appears likely that C3a and C5a may be responsible for some of the pathophysiological alterations observed following thermal injury.
热损伤后，补体激活产生过敏毒素（C3a和C5a）。我们连续测量了18例严重烧伤患者（平均烧伤面积为体表面积的37.9%）伤后最初3周内的C3a和C5a水平。与正常对照组相比，C3a值显著升高，在第二周达到最高水平，而C5a水平最初略有升高。这些水平与组织损伤程度、脓毒症并发症的发生或临床结局均无相关性。然而，C3a和C5a似乎可能是热损伤后观察到的一些病理生理改变的原因。
