Zhang Pan, Liu Fang, Cha Yin, Zhang Xiuying, Cao Mei
Department of Dermatology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, People's Republic of China.
Department of Dermatology, Dali Bai Autonomous Prefecture People's Hospital, Dali, Yunnan Province, People's Republic of China.
Clin Cosmet Investig Dermatol. 2021 Dec 24;14:1879-1884. doi: 10.2147/CCID.S343815. eCollection 2021.
Rosai-Dorfman disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy (SHML), is a rare, benign, and self-limiting disease. Cutaneous Rosai-Dorfman disease (CRDD) is an exceedingly rare extranodal variant, which is strictly limited to the skin and is easily misdiagnosed. We present the case of a 47-year-old Chinese woman with primary CRDD and a review of relevant literature. The patient had red-yellow papules on her left cheek and chest for more than three months with occasional tenderness. Histopathology showed phagocytic histiocytes in the dermis with the typical presentation of emperipolesis. Immunohistochemistry (IHC) staining showed S100 (+), CD68 (+), and CD1a (-). Based on these findings and the negative systemic presentation, the patient was diagnosed with primary papulonodular-type CRDD, and no treatment regimen was initiated. After three months, the skin lesions partially disappeared, confirming the spontaneous regression of CRDD.
罗萨伊-多夫曼病（RDD），也称为伴巨大淋巴结病的窦性组织细胞增生症（SHML），是一种罕见的、良性的、自限性疾病。皮肤型罗萨伊-多夫曼病（CRDD）是一种极其罕见的结外变异型，严格局限于皮肤，容易误诊。我们报告一例47岁中国女性原发性CRDD病例，并对相关文献进行综述。患者左脸颊和胸部出现红黄丘疹三个多月，偶尔有压痛。组织病理学显示真皮内有吞噬性组织细胞，具有典型的血细胞吞噬现象。免疫组织化学（IHC）染色显示S100（+）、CD68（+）和CD1a（-）。基于这些发现以及全身无异常表现，该患者被诊断为原发性丘疹结节型CRDD，未启动任何治疗方案。三个月后，皮肤病变部分消失，证实CRDD可自发消退。
