Bull World Health Organ. 1987;65(3):289-93.
Although influenza remains an important disease causing high levels of morbidity in many countries, the impact of epidemics can be reduced by immunoprophylaxis with available inactivated or cold-adapted live attenuated influenza vaccines. In closed or semi-closed communities, maximum benefit from immunization is likely to be achieved when more than 75% of the population are immunized. Other strategies to reduce the impact of influenza include mass immunization of certain populations to protect them as well as to reduce illness in the overall community. Adequate studies have not yet been undertaken to confirm whether the desired reduction in community-wide illnesses results from such target mass immunization programmes. Well-controlled studies to assess further the efficacy of influenza vaccines in not only protecting the vaccinee but also reducing the impact of influenza epidemics in the community should be encouraged.
尽管流感在许多国家仍然是一种导致高发病率的重要疾病，但通过使用现有的灭活或冷适应减毒活流感疫苗进行免疫预防，可以降低流感流行的影响。在封闭或半封闭社区中，当超过75%的人口接种疫苗时，免疫接种可能会获得最大效益。其他减少流感影响的策略包括对特定人群进行大规模免疫接种，以保护他们并减少整个社区的疾病。尚未进行充分的研究来证实这种目标性大规模免疫接种计划是否能实现社区范围内疾病的预期减少。应鼓励开展严格对照的研究，以进一步评估流感疫苗不仅在保护接种者方面的功效，而且在减少社区流感流行影响方面的功效。
