Department of Psychological, Huai'an No. 3 People's Hospital, Huai'an, Jiangsu 223001, China.
Comput Math Methods Med. 2021 Dec 28;2021:5309588. doi: 10.1155/2021/5309588. eCollection 2021.
The efficacy of antidepressant drugs combined with psychotherapy is controversial; hence, this meta-analysis was conducted to assess the efficacy of the combination therapy.
Relevant literature was searched in PubMed, Web of Science and Embase, Chinese databases CNKI, and WanFang Data. We included the literature on the comparison of the sertraline combined with cognitive behavioral therapy (CBT) and each treatment alone for adolescent depression published in 2000-2021. Meta-analysis was performed using Stata16.0 software.
A total of 421 relevant articles were retrieved, and 14 studies were finally included. In comparison with the control group (sertraline), sertraline combined with CBT achieved higher response rate (OR = 5.07, 95% CI: 3.00, 8.58) and lower incidence of adverse reactions (OR = 0.43, 95% CI: 0.24, 0.75). Before treatment, there were no significant differences in depression score, anxiety score, and symptom self-rating scale score between the two groups. After treatment, depression score (SMD = -2.79, 95% CI: -3.64, -1.94), anxiety score (SMD = -1.22, 95% CI: -1.96, -0.47), and symptom self-rating scale score (SMD = -1.73, 95% CI: -3.19, -0.27) were significantly lower in the combined treatment group than in the control group.
Although the number of comparative trials is small, this study shows that sertraline is effective for adolescent depression, but sertraline combined with CBT is more effective. The latter can significantly reduce the incidence of depressive symptoms, anxiety, and adverse reactions in patients. Therefore, this combination therapy is recommended for the clinical treatment of adolescent depression.
抗抑郁药联合心理疗法的疗效存在争议；因此，进行这项荟萃分析以评估联合治疗的疗效。
在 PubMed、Web of Science 和 Embase、中国的 CNKI 和万方数据等数据库中检索相关文献。纳入 2000 年至 2021 年发表的比较舍曲林联合认知行为疗法（CBT）与单独治疗青少年抑郁症的文献。使用 Stata16.0 软件进行荟萃分析。
共检索到 421 篇相关文章，最终纳入 14 项研究。与对照组（舍曲林）相比，舍曲林联合 CBT 具有更高的应答率（OR=5.07，95%CI：3.00，8.58）和更低的不良反应发生率（OR=0.43，95%CI：0.24，0.75）。治疗前，两组的抑郁评分、焦虑评分和症状自评量表评分无显著差异。治疗后，联合治疗组的抑郁评分（SMD=-2.79，95%CI：-3.64，-1.94）、焦虑评分（SMD=-1.22，95%CI：-1.96，-0.47）和症状自评量表评分（SMD=-1.73，95%CI：-3.19，-0.27）均显著低于对照组。
尽管比较试验的数量较少，但本研究表明舍曲林对青少年抑郁症有效，但舍曲林联合 CBT 更有效。后者可显著降低患者抑郁症状、焦虑和不良反应的发生率。因此，建议将这种联合疗法用于青少年抑郁症的临床治疗。
