Faculty of Nutrition of the Federal University of Alagoas, Avenida Lourival de Melo Mota, s/nº - Tabuleiro dos Martins, Maceió, Alagoas, 57072-900, Brazil.
School of Nutrition of the Federal University of Bahia, Avenida Adhemar de Barros, s/nº - Ondina, Salvador, Bahia, 40170-110, Brazil.
Arch Gynecol Obstet. 2022 Jun;305(6):1453-1463. doi: 10.1007/s00404-021-06313-2. Epub 2022 Jan 7.
Evaluating the association between serum uric acid levels and biochemical parameters linked to preeclampsia (PE) severity and to adverse perinatal outcomes.
Cross-sectional study. Information about gestational and biochemical parameters were collected before delivery, whereas perinatal outcomes were observed after it. Pregnant women were divided into hyperuricemia-HU (uric acid ≥ 6 mg/dL) or normouricemia (uric acid, 2.6-5.9 mg/dL) groups. Poisson regression models (prevalence ratio-PR; 95% confidence interval-95% CI), multinomial logistic regression (odds ratio-OR; 95% CI), and Pearson's correlation (correlation coefficient-r) were applied by taking into consideration p < 0.05 as significance level.
The total sample comprised 267 pregnant women with PE. HU was observed in 25.8% of patients; it was associated with black pregnant women (p = 0.014) and with primiparity (p = 0.007). Uric acid levels were higher in early PE cases than in late PE cases (p = 0.013); however, there was no significant difference between mild and severe PE cases (p = 0.121). Uric acid recorded a positive correlation to urea (p < 0.001), creatinine (p = 0.002), glutamic-oxaloacetic transaminase (p < 0.001), glutamic-pyruvic transaminase (p = 0.005), ferritin (p = 0.002) and globulin (p = 0.002); as well as negative correlation to platelets (p = 0.035), lactic dehydrogenase (p = 0.039) and albumin (p > 0.001). HU was a factor associated with cesarean delivery (p = 0.030), prematurity (p = 0.001), low birth weight (p < 0.001) and small for gestational age (p = 0.020).
High serum uric acid levels were associated with early-onset PE. Maternal features were correlated to biochemical parameters linked to PE severity and to adverse perinatal outcomes.
评估血清尿酸水平与子痫前期（PE）严重程度和不良围产结局相关的生化参数之间的关联。
这是一项横断面研究。在分娩前收集有关妊娠和生化参数的信息，而在分娩后观察围产儿结局。将孕妇分为高尿酸血症组（尿酸≥6mg/dL）或正常尿酸血症组（尿酸 2.6-5.9mg/dL）。采用泊松回归模型（患病率比-PR；95%置信区间-95%CI）、多项逻辑回归（比值比-OR；95%CI）和 Pearson 相关（相关系数-r），以 p<0.05 为显著性水平。
总样本包括 267 例患有 PE 的孕妇。25.8%的患者出现高尿酸血症；它与黑人孕妇（p=0.014）和初产妇（p=0.007）有关。与晚发型 PE 相比，早发型 PE 患者的尿酸水平更高（p=0.013）；然而，轻度和重度 PE 患者之间无显著差异（p=0.121）。尿酸与尿素（p<0.001）、肌酐（p=0.002）、谷草转氨酶（p<0.001）、谷丙转氨酶（p=0.005）、铁蛋白（p=0.002）和球蛋白（p=0.002）呈正相关；与血小板（p=0.035）、乳酸脱氢酶（p=0.039）和白蛋白（p>0.001）呈负相关。高尿酸血症与剖宫产（p=0.030）、早产（p=0.001）、低出生体重（p<0.001）和小于胎龄儿（p=0.020）有关。
高血清尿酸水平与早发型 PE 相关。母体特征与与 PE 严重程度和不良围产结局相关的生化参数有关。
