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Obstet Gynecol. 2023 Nov 1;142(5):1087-1095. doi: 10.1097/AOG.0000000000005367. Epub 2023 Sep 13.
2
Elevated serum uric acid level is associated with adverse reproductive outcomes in women with polycystic ovary syndrome undergoing in vitro fertilization or intracytoplasmic sperm injection embryo transfer cycles: a retrospective cohort study.血清尿酸水平升高与接受体外受精或胞浆内单精子注射胚胎移植周期的多囊卵巢综合征女性不良生殖结局相关：一项回顾性队列研究。
Am J Obstet Gynecol. 2023 Mar;228(3):324.e1-324.e10. doi: 10.1016/j.ajog.2022.11.1287. Epub 2022 Nov 17.
3
U-shaped association of uric acid to overall-cause mortality and its impact on clinical management of hyperuricemia.尿酸与全因死亡率的 U 型关联及其对高尿酸血症临床管理的影响。
Redox Biol. 2022 May;51:102271. doi: 10.1016/j.redox.2022.102271. Epub 2022 Feb 17.
4
Serum uric acid levels associated with biochemical parameters linked to preeclampsia severity and to adverse perinatal outcomes.血清尿酸水平与子痫前期严重程度及不良围生结局相关的生化参数相关联。
Arch Gynecol Obstet. 2022 Jun;305(6):1453-1463. doi: 10.1007/s00404-021-06313-2. Epub 2022 Jan 7.
5
Serum uric acid change in relation to antihypertensive therapy with the dihydropyridine calcium channel blockers.血清尿酸变化与二氢吡啶类钙通道阻滞剂降压治疗的关系。
Blood Press. 2021 Dec;30(6):395-402. doi: 10.1080/08037051.2021.1996220. Epub 2021 Oct 29.
6
Chronic Low Grade Inflammation in Pathogenesis of PCOS.多囊卵巢综合征发病机制中的慢性低度炎症。
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7
Uric acid participating in female reproductive disorders: a review.尿酸参与女性生殖系统疾病：综述。
Reprod Biol Endocrinol. 2021 Apr 27;19(1):65. doi: 10.1186/s12958-021-00748-7.
8
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9
Association between serum uric acid and obesity in Chinese adults: a 9-year longitudinal data analysis.中国成年人血清尿酸与肥胖之间的关联：一项9年纵向数据分析。
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Association between plasma uric acid and insulin resistance in type 2 diabetes: A Mendelian randomization analysis.血浆尿酸与 2 型糖尿病胰岛素抵抗的关系：孟德尔随机分析。
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血清尿酸水平对 PCOS 不孕女性 IVF 胚胎和妊娠结局无影响。

Serum uric acid did not affect embryonic and pregnancy outcomes in women without PCOS during IVF procedures.

机构信息

Reproductive Medicine Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Guangdong Provincial Key Laboratory of Reproductive Medicine, Guangzhou, China.

出版信息

Front Endocrinol (Lausanne). 2024 Feb 16;15:1310122. doi: 10.3389/fendo.2024.1310122. eCollection 2024.

DOI:10.3389/fendo.2024.1310122
PMID:38444583
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10912854/
Abstract

OBJECTIVES

Serum uric acid (UA) levels are associated with many systemic diseases. A previous study confirmed the association between high serum uric acid levels and poor prognosis of fertilization (IVF) treatment in polycystic ovary syndrome (PCOS) patients. This study aimed to explore the correlation between serum uric acid levels and reproductive outcomes in patients without PCOS.

METHODS

A retrospective study that included 1057 patients who underwent pre-implantation genetic testing for monogenic disorders (PGT-M) treatment from January 2013 to December 2020 was conducted. The study population was further divided into 3 groups according to serum UA levels: the ≤250 μmol/L group, the 251-360 μmol/L group, and the >360 μmol/L group. The controlled ovarian hyperstimulation (COH) treatment outcomes, embryonic treatment outcomes and pregnancy outcomes of the first frozen embryo transfer (FET) cycle were compared among groups. Multivariable linear regression and binary regression were applied to detect the association between IVF outcomes and serum uric acid levels.

RESULTS

The number of retrieved oocytes, fertilization rate, viable embryo rate, blastocyst formation rate and euploid rate were not associated with serum uric acid levels. The mature oocyte rate was negatively correlated with serum uric acid levels. The pregnancy outcomes of the first FET cycle were also not associated with serum uric acid levels. After adjustment for BMI, the perinatal outcomes were not associated with serum uric acid levels.

CONCLUSION

IVF treatment outcomes were not associated with serum uric acid levels in patients without PCOS.

摘要

目的

血清尿酸（UA）水平与许多系统性疾病有关。先前的研究证实，高血清尿酸水平与多囊卵巢综合征（PCOS）患者体外受精（IVF）治疗预后不良有关。本研究旨在探讨血清尿酸水平与非 PCOS 患者生殖结局的相关性。

方法

这是一项回顾性研究，纳入了 2013 年 1 月至 2020 年 12 月期间因单基因疾病（PGT-M）接受胚胎植入前遗传学检测治疗的 1057 例患者。根据血清 UA 水平将研究人群进一步分为 3 组：≤250μmol/L 组、251-360μmol/L 组和>360μmol/L 组。比较各组控制性卵巢刺激（COH）治疗结局、胚胎治疗结局和首次冻融胚胎移植（FET）周期的妊娠结局。应用多变量线性回归和二项回归检测 IVF 结局与血清尿酸水平之间的关系。

结果

获卵数、受精率、可利用胚胎率、囊胚形成率和整倍体率与血清尿酸水平无关。成熟卵率与血清尿酸水平呈负相关。首次 FET 周期的妊娠结局也与血清尿酸水平无关。调整 BMI 后，围产期结局与血清尿酸水平无关。

结论

在非 PCOS 患者中，IVF 治疗结局与血清尿酸水平无关。