Benkmann H G, Hanssen H P, Ovenbeck R, Goedde H W
Institute of Human Genetics, University of Hamburg, FRG.
Hum Hered. 1987;37(5):290-3. doi: 10.1159/000153720.
Frequencies of the alpha 1-antitrypsin (Pi) alleles and haptoglobin phenotypes have been determined in a series of 264 North-German patients with bladder cancer. Compared to a healthy control population, we found a statistically significant decrease of Hp 2-2 phenotype in the patient series. A significant increase of the serum Pi Z allele, as previously shown for patient groups with certain other tumours, could also be confirmed for bladder cancer. Furthermore, a distinct association between a lowered M 3 allele and bladder carcinoma was observed.
在一组264名北德膀胱癌患者中，已确定了α1-抗胰蛋白酶（Pi）等位基因和触珠蛋白表型的频率。与健康对照人群相比，我们发现患者组中Hp 2-2表型在统计学上显著降低。正如之前在其他某些肿瘤患者组中所显示的那样，膀胱癌患者血清Pi Z等位基因也有显著增加。此外，还观察到M 3等位基因降低与膀胱癌之间存在明显关联。
