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阿魏酸通过抑制 NO/p21 信号通路减轻动脉粥样硬化斑块中血管平滑肌细胞的增殖。

Ferulic Acid Alleviates Atherosclerotic Plaques by Inhibiting VSMC Proliferation Through the NO/p21 Signaling pathway.

机构信息

Medical College, Xiamen University, Xiamen, 361102, China.

School of Basic Medicine, Gannan Medical University, Ganzhou, 341000, China.

出版信息

J Cardiovasc Transl Res. 2022 Aug;15(4):865-875. doi: 10.1007/s12265-021-10196-8. Epub 2022 Jan 6.

DOI:10.1007/s12265-021-10196-8
PMID:34993756
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9622559/
Abstract

The benefits and risks of inhibiting the proliferation and migration of vascular smooth muscle cells (VSMCs) in atherosclerosis (AS) remain a subject of debate. In this study, we investigated the effect of ferulic acid (FA) on the proliferation and migration of VSMCs induced by platelet-derived growth factor (PDGF) and the associated mechanism and used ApoE mice to study whether the effect of FA on VSMC proliferation and migration is beneficial in alleviating AS plaques. It was found that FA not only reduced blood lipid levels but also promoted the production of nitric oxide (NO) by MOVAS cells through the endothelial nitric oxide synthase (eNOS) pathway, inhibited the migration and proliferation of VSMCs induced by PDGF, promoted the expression of p21 in VSMCs, and exerted a therapeutic effect against AS.

摘要

抑制动脉粥样硬化（AS）中血管平滑肌细胞（VSMCs）增殖和迁移的益处和风险仍然存在争议。在这项研究中，我们研究了阿魏酸（FA）对血小板衍生生长因子（PDGF）诱导的 VSMCs 增殖和迁移的影响及其相关机制，并使用载脂蛋白 E （ApoE） 小鼠研究 FA 是否对 VSMC 增殖和迁移有有益作用，从而缓解 AS 斑块。结果发现，FA 不仅降低了血脂水平，还通过内皮型一氧化氮合酶（eNOS）途径促进 MOVAS 细胞产生一氧化氮（NO），抑制 PDGF 诱导的 VSMCs 迁移和增殖，促进 VSMCs 中 p21 的表达，对 AS 具有治疗作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8588/9622559/257ee5ddf625/12265_2021_10196_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8588/9622559/91f6764f7b9a/12265_2021_10196_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8588/9622559/1de432e37073/12265_2021_10196_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8588/9622559/8c10761e785f/12265_2021_10196_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8588/9622559/492e2df2bbcf/12265_2021_10196_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8588/9622559/20d941aa7ac5/12265_2021_10196_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8588/9622559/257ee5ddf625/12265_2021_10196_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8588/9622559/91f6764f7b9a/12265_2021_10196_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8588/9622559/1de432e37073/12265_2021_10196_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8588/9622559/8c10761e785f/12265_2021_10196_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8588/9622559/492e2df2bbcf/12265_2021_10196_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8588/9622559/20d941aa7ac5/12265_2021_10196_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8588/9622559/257ee5ddf625/12265_2021_10196_Fig6_HTML.jpg

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