接种 COVID-19 疫苗后的孤立性血栓形成：病例系列。
Isolated thrombosis after COVID-19 vaccination: case series.
机构信息
Microbiology Department, Faculty of Medicine, Kuwait University, P.O. Box 24923, 13110, Safat, Kuwait.
Al Rashed Allergy Centre, Ministry of Health, Kuwait, Kuwait.
出版信息
Int J Hematol. 2022 Feb;115(2):153-157. doi: 10.1007/s12185-021-03285-6. Epub 2022 Jan 6.
BACKGROUND
Data regarding thrombosis after COVID-19 vaccination are scarce.
METHODS
Clinical and laboratory data were collected from all patients who developed thrombosis within 4 weeks of receiving the Pfizer or Oxford/AstraZeneca vaccine. None had a COVID-19-positive swab.
RESULTS
Seventeen patients were included, with average age of 48.8 years and equal proportion of females to males. Our data suggest that thrombosis occurred in 1 in 163,000 of all individuals who had received any dose of any type of COVID-19 vaccine: six (1 in 123,000) patients after the first dose of Oxford/AstraZeneca, none after the second dose of Oxford/AstraZeneca, four (1 in 257,000) patients after the first dose of the Pfizer vaccine, and seven (1 in 102,000) patients after the second dose of Pfizer vaccine. Three of 17 patients with thrombosis (17.6%) died.
CONCLUSIONS
We believe this report to be one of the earliest in the literature to address the question of whether isolated thrombosis is a possible complication of COVID-19 vaccination.
背景
关于 COVID-19 疫苗接种后血栓形成的数据很少。
方法
从所有在接种辉瑞或牛津/阿斯利康疫苗后 4 周内发生血栓的患者中收集临床和实验室数据。这些患者均未进行 COVID-19 阳性拭子检测。
结果
共纳入 17 例患者，平均年龄为 48.8 岁，男女比例相等。我们的数据表明，在所有接种过任何类型 COVID-19 疫苗的人群中，每 16.3 万人中就有 1 人发生血栓：6 例（每 12.3 万人中 1 例）在接种牛津/阿斯利康疫苗第一剂后，第二剂后无此现象；4 例（每 25.7 万人中 1 例）在接种辉瑞疫苗第一剂后，7 例（每 10.2 万人中 1 例）在接种辉瑞疫苗第二剂后。17 例血栓形成患者中有 3 例（17.6%）死亡。
结论
我们认为这是文献中最早探讨孤立性血栓形成是否是 COVID-19 疫苗接种的一种可能并发症的报告之一。
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