Research Center for Analytical Science, State Key Laboratory of Medicinal Chemical Biology and Tianjin Key Laboratory of Biosensing and Molecular Recognition, College of Chemistry, Nankai University, 94 Weijin Road, Tianjin, 300071, China.
Central Laboratory, Nankai University, Tianjin, 300071, China.
Mikrochim Acta. 2022 Jan 7;189(2):51. doi: 10.1007/s00604-021-05143-y.
Efficient determination of aldehydes by matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) is hampered mainly by the low mass and unstable nature of analytes. In the present work, we propose a combined strategy of a reactive metal-organic framework (MOF) matrix for the derivatization and detection of aldehydes. A novel reactive MOF matrix (NHNH-MOF) was synthesized in two steps. First, NR-MOF was synthesized via Cu and the quaternary amine ligand 4,4'-bipyridinium, 1,1″-(1,2-ethanediyl)bis-, dibromide (PyEtBr). Then, -NHNH was introduced to NR-MOF through electrostatic adsorption between the -NR and -HSO of 4-hydrazinylbenzenesulfonic acid to synthesize NHNH-MOF. The acid-base chemistry of NHNH-MOF led to uniform cocrystallization of the aldehyde-matrix mixtures and helped to achieve the detection of low-weight aldehydes with good relative standard deviations (RSDs = 0.07-12.35%). It was confirmed that this strategy can accurately quantify formaldehyde, valeraldehyde, and benzaldehyde with good linearity (r > 0.97). Furthermore, this strategy was applied to quantitatively detect benzaldehyde in wastewater, thus showing potential applications in environmental pollutant detection.
基质辅助激光解吸电离质谱（MALDI-MS）对醛类物质的高效测定主要受到分析物质量低和不稳定的限制。在本工作中，我们提出了一种用于醛类衍生化和检测的反应性金属有机骨架（MOF）基质的联合策略。通过两步法合成了一种新型反应性 MOF 基质（NHNH-MOF）。首先，通过 Cu 和季铵配体 4,4'-联吡啶，1,1"-(1,2-乙二基)双，二溴化物（PyEtBr）合成了 NR-MOF。然后，通过 4-肼基苯磺酸的-NR 和 -HSO 之间的静电吸附，将-NHNH 引入到 NR-MOF 中，从而合成了 NHNH-MOF。NHNH-MOF 的酸碱化学导致醛-基质混合物的均匀共结晶，并有助于实现低分子量醛的良好相对标准偏差（RSDs=0.07-12.35%）检测。实验证实，该策略可以准确地定量检测甲醛、戊醛和苯甲醛，具有良好的线性度（r＞0.97）。此外，该策略还应用于废水中苯甲醛的定量检测，因此显示出在环境污染物检测方面的潜在应用。
