Zheng Ruijuan, Yang Yingchen, Yang Chang, Xia Yan
Research Center for Analytical Sciences, State Key Laboratory of Medicinal Chemical Biology, and Tianjin Key Laboratory of Biosensing and Molecular Recognition, College of Chemistry, Nankai University, 94 Weijin Road, Tianjin, 300071, China.
Central Laboratory, Nankai University, Tianjin, 300071, China.
Mikrochim Acta. 2021 Apr 29;188(5):179. doi: 10.1007/s00604-021-04832-y.
A core-shell material (UiO@TapbTp) has been developed as an adsorbent and matrix to detect nonsteroidal anti-inflammatory drugs (NSAIDS) by matrix laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) in complex samples. The hybrid material is prepared by growing covalent organic framework (COF, TapbTp) layers in situ on an amino-modified metal-organic framework (MOF, UiO-66-NH). The combination of the MOF and COF overcomes their individual shortcomings and integrates both of their advantages. Compared with the bare COF and MOF, the core-shell composite exhibits improved enrichment ability and matrix performance. With the help of pre-enrichment under optimized conditions, the limits of detection (LODs) for ketoprofen, naproxen, and aspirin are reduced by nearly 1000 times, with values of 0.001 mg L, 0.010 mg L, and 0.001 mg L, respectively, and the relative standard deviations (RSDs) are all below 12.35%. The good recoveries (84.8-118%) in (spiked) saliva and environmental water sample further verify the applicability of the method in complex samples.
一种核壳材料（UiO@TapbTp）已被开发用作吸附剂和基质，通过基质辅助激光解吸/电离飞行时间质谱（MALDI-TOF MS）检测复杂样品中的非甾体抗炎药（NSAIDs）。这种杂化材料是通过在氨基修饰的金属有机框架（MOF，UiO-66-NH）上原位生长共价有机框架（COF，TapbTp）层制备而成。MOF和COF的结合克服了它们各自的缺点，并整合了两者的优点。与裸COF和MOF相比，核壳复合材料表现出更好的富集能力和基质性能。在优化条件下进行预富集，酮洛芬、萘普生和阿司匹林的检测限（LOD）分别降低了近1000倍，达到0.001 mg/L、0.010 mg/L和0.001 mg/L，相对标准偏差（RSD）均低于12.35%。在（加标）唾液和环境水样中的良好回收率（84.8-118%）进一步验证了该方法在复杂样品中的适用性。
