Speer C P, Rethwilm M, Gahr M
Department of Pediatrics, University of Göttingen, F.R.G.
J Pediatr. 1987 Nov;111(5):667-71. doi: 10.1016/s0022-3476(87)80240-8.
In 26 infants and children with septicemia or bacterial meningitis, significantly elevated plasma levels of elastase-alpha 1-proteinase inhibitor (E-alpha 1-PI) were present at time of recognition of infection, even in those patients with neutropenia (range of reference values: 25 to 190 micrograms/L, n = 142; patients: 444 to 2049 micrograms/L, n = 26). After initiation of therapy, normalization of E-alpha 1-PI levels was observed in all patients who recovered from infection. In addition, 18 of 19 children with bacterial meningitis had increased cerebrospinal fluid concentrations of E-alpha 1-PI above the range of normal (range of reference values: 0 to 39 micrograms/L, n = 62; patients: 30 to 3490 micrograms/L, n = 19); concentrations of E-alpha 1-PI in bacterial meningitis were significantly increased when compared with those in aseptic meningitis (range 25 to 194 micrograms/L; n = 15). In 30 patients with local bacterial infections (pneumonia, urinary tract infections, etc.), E-alpha 1-PI was also elevated. These data suggest that E-alpha 1-PI is a sensitive indicator of systemic and local bacterial infection in childhood.
在26例患有败血症或细菌性脑膜炎的婴幼儿中，即使是那些中性粒细胞减少的患者，在确诊感染时血浆中弹性蛋白酶-α1-蛋白酶抑制剂（E-α1-PI）水平也显著升高（参考值范围：25至190微克/升，n = 142；患者：444至2049微克/升，n = 26）。开始治疗后，所有从感染中康复的患者E-α1-PI水平均恢复正常。此外，19例细菌性脑膜炎患儿中有18例脑脊液中E-α1-PI浓度高于正常范围（参考值范围：0至39微克/升，n = 62；患者：30至3490微克/升，n = 19）；与无菌性脑膜炎（范围25至194微克/升；n = 15）相比，细菌性脑膜炎中E-α1-PI浓度显著升高。在30例局部细菌感染（肺炎、尿路感染等）患者中，E-α1-PI也升高。这些数据表明，E-α1-PI是儿童全身和局部细菌感染的敏感指标。
