Andus T, Gross V, Caesar I, Krumm D, Hosp J, Gerok W, Schölmerich J
Department of Internal Medicine, University of Freiburg, Germany.
Dig Dis Sci. 1993 Sep;38(9):1638-44. doi: 10.1007/BF01303172.
PMN-elastase is a proteinase released by activated neutrophils. PMN-elastase was determined in two independent populations with inflammatory bowel disease. In an unselected population of 70 consecutive patients with Crohn's disease and 24 patients with ulcerative colitis with different degrees of disease activity plasma PMN-elastase levels were statistically significantly higher in patients with active than in patients with inactive disease [Crohn's disease: 80.5 +/- 33.2 ng/ml vs 60.1 +/- 24.6 ng/ml (mean +/- SD), P = 0.0017; ulcerative colitis: 98.2 +/- 54.9 ng/ml vs 59.2 +/- 16.8 ng/ml, P = 0.026]. PMN-elastase levels in feces were also higher in patients with active Crohn's disease (23.6 +/- 15.3 ng/g vs 13.6 +/- 12.5 ng/g, P = 0.0021) and active ulcerative colitis (46.5 +/- 60.5 ng/g vs 20.2 +/- 25.0 ng/g, P = 0.46), but the difference reached significance only in Crohn's disease. Correlation of disease activity and PMN-elastase in individual patients showed a statistically significant correlation between plasma and fecal elastase concentrations and disease activity in ulcerative colitis (plasma: r = 0.72, P < 0.001; feces: r = 0.57, P = 0.002). In patients with Crohn's disease only plasma levels of PMN-elastase (r = 0.423, P < 0.001) but not fecal elastase concentrations (r = 0.0083, P = 0.485) correlated significantly with disease activity. Plasma PMN-elastase correlated weakly with fecal PMN-elastase levels in Crohn's disease (r = 0.431, P < 0.01) and in ulcerative colitis (r = 0.515, P = 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
中性粒细胞弹性蛋白酶是一种由活化的中性粒细胞释放的蛋白酶。在两个独立的炎症性肠病患者群体中测定了中性粒细胞弹性蛋白酶。在一个由70例连续的克罗恩病患者和24例溃疡性结肠炎患者组成的未经过筛选的群体中，这些患者具有不同程度的疾病活动度，活动期患者血浆中的中性粒细胞弹性蛋白酶水平在统计学上显著高于非活动期患者[克罗恩病：80.5±33.2纳克/毫升对60.1±24.6纳克/毫升（均值±标准差），P = 0.0017；溃疡性结肠炎：98.2±54.9纳克/毫升对59.2±16.8纳克/毫升，P = 0.026]。活动期克罗恩病患者粪便中的中性粒细胞弹性蛋白酶水平也较高（23.6±15.3纳克/克对13.6±12.5纳克/克，P = 0.0021），活动期溃疡性结肠炎患者粪便中的中性粒细胞弹性蛋白酶水平也较高（46.5±60.5纳克/克对20.2±25.0纳克/克，P = 0.46），但差异仅在克罗恩病中具有统计学意义。个体患者疾病活动度与中性粒细胞弹性蛋白酶的相关性显示，溃疡性结肠炎患者血浆和粪便弹性蛋白酶浓度与疾病活动度之间存在统计学显著相关性（血浆：r = 0.72，P < 0.001；粪便：r = 0.57，P = 0.002）。在克罗恩病患者中，仅血浆中的中性粒细胞弹性蛋白酶水平（r = 0.423，P < 0.001）与疾病活动度显著相关，而粪便弹性蛋白酶浓度（r = 0.0083，P = 0.485）与疾病活动度无显著相关性。克罗恩病患者血浆中性粒细胞弹性蛋白酶与粪便中性粒细胞弹性蛋白酶水平呈弱相关（r = 0.431，P < 0.01），溃疡性结肠炎患者中二者也呈弱相关（r = 0.515，P = 0.05）。（摘要截断于250字）
