核破坏：AKIRIN2 通过自杀任务将完整的蛋白酶体带入细胞核。
Nuclear destruction: A suicide mission by AKIRIN2 brings intact proteasomes into the nucleus.
机构信息
Protein Processing Section, Center for Structural Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.
Protein Processing Section, Center for Structural Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.
出版信息
Mol Cell. 2022 Jan 6;82(1):13-14. doi: 10.1016/j.molcel.2021.11.020.
Abstract
de Almeida et al. (2021) developed a temporally controlled CRISPR-Cas9 screen to identify mechanisms controlling MYC levels and discovered that intact proteasomes are imported into the nucleus by AKIRIN2 binding to proteasomes at one end and a nuclear import receptor at the other.
摘要
德阿尔梅达等人（2021 年）开发了一种时间控制的 CRISPR-Cas9 筛选技术，以鉴定控制 MYC 水平的机制，并发现完整的蛋白酶体通过 AKIRIN2 与蛋白酶体的一端结合，与另一端的核输入受体结合，被导入细胞核。
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