Department of Pharmacy, College of Chemical Engineering, Qingdao University of Science and Technology, Zhengzhou Road 53, Qingdao 266042, China.
School of Agricultural Engineering and Food Science, Shandong University of Technology, Xincun West Road 266, Zibo 255000, China.
Int J Biol Macromol. 2022 Mar 15;201:14-19. doi: 10.1016/j.ijbiomac.2021.12.156. Epub 2022 Jan 4.
Advanced dressings that can simultaneously prevent bacterial colonization/infection and reduce inflammation are highly desired. A simple strategy was developed to incorporate an anti-inflammatory and antibacterial drug rhein into the structure of silk fibroin (SF) matrix to fabricate a hydrogel dressing. The SF/Rhein hydrogels showed fibrous network nanostructure, high water content (~90%), high water adsorption ability (>2 folds of its own weight), acceptable mechanical strength, biocompatibility and antibacterial properties, suitable as dressings for the treatment of bacterial infected wounds. The SF/Rhein hydrogels enhanced the healing rate of burn wounds by reducing inflammation, expediting angiogenesis, and promoting skin appendages formation, being a promising candidate as wound dressings.
人们非常希望有一种能够同时预防细菌定植/感染和减轻炎症的高级敷料。本研究开发了一种简单的策略，即将具有抗炎和抗菌作用的药物大黄素(rhein)掺入丝素蛋白(SF)基质的结构中，以制备水凝胶敷料。SF/大黄素水凝胶具有纤维状网络纳米结构、高含水量（~90%）、高吸水性（>自身重量的 2 倍）、可接受的机械强度、生物相容性和抗菌性能，适合用作治疗细菌感染伤口的敷料。SF/大黄素水凝胶通过减轻炎症、加速血管生成和促进皮肤附属物形成来提高烧伤创面的愈合率，是一种很有前途的创面敷料候选物。
