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用于伤口愈合的节肢动物启发型仿生材料的进展。

Advances in arthropod-inspired bionic materials for wound healing.

作者信息

Li Yuchen, Cui Jiaming, Xiao Di, Cao Bixuan, Wei Jing, Wang Qian, Zong Junwei, Wang Jinwu, Song Mingzhi

机构信息

School of Pharmacy, Jiangsu Ocean University, Lianyungang, Jiangsu, China.

Department of Orthopedics, Nantong City No. 1 People's Hospital and Second Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.

出版信息

Mater Today Bio. 2024 Oct 22;29:101307. doi: 10.1016/j.mtbio.2024.101307. eCollection 2024 Dec.

Abstract

Arthropods contain lots of valuable bionic information from the composition to the special structure of the body. In particular, the rapid self-healing ability and antibacterial properties are amazing. Biomimetic materials for arthropods have been helpful methods for wound management. Here, we have identified four major dimensions needed to create biomimetic materials for arthropods, including ingredient, behavior, structure and internal reaction. According to different dimensions, we classify and introduce the reported arthropod biomimetic materials. Antibacterial, hemostatic and healing promotion are the main functions of the active compositions of arthropods developed by humans, and most of them play a drug effect. We believe that an ideal biomimetic material of arthropod should have the effect on promoting wound healing through the advantages of structure and composition. The special macroscopic and microscopic structure of the epidermis may provide good mechanical support for biomimetic materials. The drug release regularity in the bionic materials can be referred to the aggressive and secretory behavior of arthropods. The synthesis of substances in arthropods is also noteworthy, and we can learn these special reactions to complete the fast preparation of materials. Arthropod-inspired bionic materials have broad innovation and application prospects in the field of wound repair.

摘要

节肢动物蕴含着从组成到身体特殊结构的大量宝贵仿生信息。特别是其快速自愈能力和抗菌特性令人惊叹。用于节肢动物的仿生材料一直是伤口处理的有效方法。在此,我们确定了制造节肢动物仿生材料所需的四个主要维度,包括成分、行为、结构和内部反应。根据不同维度,我们对已报道的节肢动物仿生材料进行分类和介绍。抗菌、止血和促进愈合是人类开发的节肢动物活性成分的主要功能,其中大多数发挥着药物作用。我们认为,理想的节肢动物仿生材料应通过结构和成分优势对促进伤口愈合产生作用。表皮特殊的宏观和微观结构可为仿生材料提供良好的机械支撑。仿生材料中的药物释放规律可参考节肢动物的攻击和分泌行为。节肢动物体内物质的合成也值得关注,我们可以借鉴这些特殊反应来完成材料的快速制备。受节肢动物启发的仿生材料在伤口修复领域具有广阔的创新和应用前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81b8/11567928/d9c5fac67a62/ga1.jpg

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