Department of Pathology and Laboratory Medicine, University of Cincinnati Medical School, Cincinnati, OH, United States of America.
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine and Magee Women's Research Institute, Pittsburgh, PA, United States of America.
Biochim Biophys Acta Mol Cell Biol Lipids. 2022 Mar;1867(3):159106. doi: 10.1016/j.bbalip.2021.159106. Epub 2022 Jan 4.
High density lipoproteins (HDL) were first linked to cardiovascular disease (CVD) over 30 years ago when an inverse relationship was shown between CVD and HDL-cholesterol levels. It is now apparent that HDL composition and function, not cholesterol levels, are the pertinent measurements describing HDL's role in various disease processes, especially those with subclinical or overt inflammation.
Pregnancy is also an inflammatory state. When inflammation becomes excessive during pregnancy, there is an increased risk for adverse outcomes that affect the health of the mother and fetus, including preterm birth and preeclampsia. Though studies on HDL during pregnancy are limited, recent evidence demonstrates that HDL composition and function change during pregnancy and in women with adverse outcomes.
In this review, we will discuss how HDL may play a role in maintaining a healthy pregnancy and how impairments in function could lead to pregnancies with adverse outcomes.
30 多年前，人们首次发现高密度脂蛋白（HDL）与心血管疾病（CVD）之间存在关联，当时研究表明 CVD 与 HDL 胆固醇水平呈负相关。现在很明显，HDL 的组成和功能，而不是胆固醇水平，是描述 HDL 在各种疾病过程中作用的相关指标，尤其是在亚临床或显性炎症的情况下。
怀孕也是一种炎症状态。当怀孕期间炎症过度时，母亲和胎儿的健康就会面临不良后果的风险增加，包括早产和子痫前期。虽然关于怀孕期间 HDL 的研究有限，但最近的证据表明，HDL 的组成和功能在怀孕期间以及在出现不良后果的女性中会发生变化。
在这篇综述中，我们将讨论 HDL 如何在维持健康妊娠中发挥作用，以及功能障碍如何导致出现不良妊娠结局。
