Massacesi L, Abbamondi A L, Sarlo F, Amaducci L
Istituto delle Malattie Nervose e Mentali, Università, Firenze.
Riv Neurol. 1987 May-Jun;57(3):166-9.
Two form of retinoic acid (RA) prevented the development of experimental allergic encephalomyelitis (EAE) in Lewis rats. RA suspended in corn oil was given before the expected onset of the disease to rats immunized with myelin and to controls. The drug suppressed the neurological symptoms as well as the perivascular infiltrates observed in vehicle treated animals. The results indicate that, under these experimental conditions, RA has immunosuppressive activity by interfering with the efferent phase of the immune response.
两种形式的视黄酸（RA）可预防Lewis大鼠实验性自身免疫性脑脊髓炎（EAE）的发生。在预期疾病发作前，将悬浮于玉米油中的RA给予用髓磷脂免疫的大鼠和对照组。该药物抑制了在赋形剂处理动物中观察到的神经症状以及血管周围浸润。结果表明，在这些实验条件下，RA通过干扰免疫反应的传出阶段而具有免疫抑制活性。
