Department of Health Statistics, School of Public Health, Inner Mongolia Medical University, Hohhot, China.
National Institute for Chronic and Non-Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
BMJ Open. 2022 Jan 7;12(1):e049351. doi: 10.1136/bmjopen-2021-049351.
Modifiable physical activity (PA) plays an important role in dyslipidaemia risk in middle-aged women with sleep problems, especially perimenopausal women. We aimed to explore the joint effects of sleep and PA on the risk of dyslipidaemia in women aged 45-55 years, and the extent to which PA moderated the effect of sleep on the risk of dyslipidaemia.
A cross-sectional study.
This study was based on the survey of Chronic Disease and Nutrition Monitoring in Adults in Inner Mongolia in 2015.
721 women aged 45-55 years were included.
PA was measured by the Global Physical Activity Questionnaire. Sleep was measured by questionnaire formulated by the Chinese Center for Disease Control and Prevention. Multivariate logistic regression analyses were performed to determine the joint effects of sleep and PA on dyslipidaemia risk. OR and 95% CI were reported.
Among all participants, 60.6% had sleep problems, 29.0% had low PA and 41.1% had dyslipidaemia. Women with sleep problems had higher dyslipidaemia risk than women without sleep problems, irrespective of low, moderate or high PA, with OR (95% CI) of 4.24 (2.40 to 7.49), 3.14 (1.80 to 5.49) and 2.04 (1.20 to 3.48), respectively. PA could not completely attenuate the negative association between sleep and dyslipidaemia risk. With PA increased from low to high, the OR of dyslipidaemia decreased by 2.20. Women with sleep problems and low PA had higher risks of high total cholesterol, high triglyceride, low high-density lipoprotein cholesterol and high low-density lipoprotein cholesterol than women without sleep problems and high PA, with OR (95% CI) of 2.51 (1.18 to 5.35), 2.42 (1.23 to 4.74), 2.88 (1.44 to 5.74) and 2.52 (1.12 to 5.70), respectively.
Among women aged 45-55 years, the joint effects of self-reported sleep and PA on dyslipidaemia risk were more marked for sleep than for PA. Modifiable PA is a widely accessible and effective intervention to reduce the dyslipidaemia risk in women with sleep problems, particularly among perimenopausal women.
可改变的体力活动（PA）在中年有睡眠问题的女性的血脂异常风险中起着重要作用，尤其是围绝经期女性。本研究旨在探讨睡眠和 PA 对 45-55 岁女性血脂异常风险的联合影响，以及 PA 对睡眠影响血脂异常风险的程度。
横断面研究。
本研究基于 2015 年内蒙古慢性病与营养监测的调查。
共纳入 721 名 45-55 岁的女性。
PA 通过全球体力活动问卷进行测量。睡眠通过中国疾病预防控制中心制定的问卷进行测量。采用多变量 logistic 回归分析确定睡眠和 PA 对血脂异常风险的联合影响。报告 OR 和 95%CI。
在所有参与者中，60.6%有睡眠问题，29.0%有低 PA，41.1%有血脂异常。有睡眠问题的女性比没有睡眠问题的女性血脂异常风险更高，无论 PA 水平是低、中还是高，OR（95%CI）分别为 4.24（2.40 至 7.49）、3.14（1.80 至 5.49）和 2.04（1.20 至 3.48）。PA 并不能完全减轻睡眠与血脂异常风险之间的负相关关系。随着 PA 从低到高增加，血脂异常的 OR 降低了 2.20。有睡眠问题和低 PA 的女性发生总胆固醇升高、甘油三酯升高、高密度脂蛋白胆固醇降低和低密度脂蛋白胆固醇升高的风险高于没有睡眠问题和高 PA 的女性，OR（95%CI）分别为 2.51（1.18 至 5.35）、2.42（1.23 至 4.74）、2.88（1.44 至 5.74）和 2.52（1.12 至 5.70）。
在 45-55 岁女性中，与 PA 相比，睡眠对血脂异常风险的联合影响更为显著。可改变的 PA 是一种广泛适用且有效的干预措施，可降低有睡眠问题的女性的血脂异常风险，尤其是围绝经期女性。
