Sheĭtanov I, Nikolov K, Petrova P
Vutr Boles. 1987;26(4):66-70.
The total hemolytic complement (CH50) was studied in the serum of 54 patients suffering from rheumatoid arthritis (RA) and in the synovia of 30 of them. The C3 complement fraction was examined in the serum of 49 patients and in the synovia of 30 patients. The C4 complement serum-fraction was examined in 42 patients and in the synovia of 30 patients. 40 healthy persons and 21 patients with osteoarthritis served as a control group. The results showed a slight increase of CH50 in the serum and decrease in the synovia of the patients with RA compared to the control groups. The serum values of C3 and C4 of the RA patients did no differ from those of the healthy persons but the synovial C3 and C4 values were lowered. A reverse correlation was found between the CH50 in the synovial fluid and the phagocyte percentage in the fluid (r = -0.43). CH50, C3 and C4 determination is important for clarification of some pathogenetic mechanisms in RA. Their decrease reflects the degree of immunologic activity.
对54例类风湿性关节炎（RA）患者的血清及其中30例患者的滑膜进行了总溶血补体（CH50）研究。检测了49例患者血清及30例患者滑膜中的C3补体成分。检测了42例患者血清及30例患者滑膜中的C4补体成分。40名健康人和21例骨关节炎患者作为对照组。结果显示，与对照组相比，RA患者血清中CH50略有升高，滑膜中CH50降低。RA患者血清C3和C4值与健康人无差异，但滑膜C3和C4值降低。发现滑液中CH50与滑液中吞噬细胞百分比呈负相关（r = -0.43）。CH50、C3和C4的测定对于阐明RA的某些发病机制很重要。它们的降低反映了免疫活性程度。
