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利用蒙特卡罗模拟研究半定量分析脑萎缩对 [I]FP-CIT 单光子发射计算机断层扫描的影响。

Influence of brain atrophy using semiquantitative analysis in [I]FP-CIT single-photon emission computed tomography by a Monte Carlo simulation study.

机构信息

Clinical Imaging Center for Healthcare, Nippon Medical School, 1-12-15 Sendagi, Bunkyo, Tokyo, 113-0022, Japan.

Department of Quantum Medical Technology, Graduate School of Medical Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa, Ishikawa, 920-0942, Japan.

出版信息

Sci Rep. 2022 Jan 7;12(1):168. doi: 10.1038/s41598-021-04078-x.

DOI:10.1038/s41598-021-04078-x
PMID:34997080
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8742003/
Abstract

The specific binding ratio (SBR) is an objective indicator of N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-[123I] iodophenyl) nortropane ([I]FP-CIT) single-photon emission computed tomography (SPECT) that could be used for the diagnosis of Parkinson's disease and Lewy body dementia. One of the issues of the SBR analysis is that the setting position of the volume of interest (VOI) may contain cerebral ventricles and cerebral grooves. These areas may become prominent during the brain atrophy analysis; however, this phenomenon has not been evaluated enough. This study thus used Monte Carlo simulations to examine the effect of brain atrophy on the SBR analysis. The brain atrophy model (BAM) used to simulate the three stages of brain atrophy was made using a morphological operation. Brain atrophy levels were defined in the descending order from 1 to 3, with Level 3 indicating to the most severe damage. Projection data were created based on BAM, and the SPECT reconstruction was performed. The ratio of the striatal to background region accumulation was set to a rate of 8:1, 6:1, and 4:1. The striatal and the reference VOI mean value were decreased as brain atrophy progressed. Additionally, the Bolt's analysis methods revealed that the reference VOI value was more affected by brain atrophy than the striatal VOI value. Finally, the calculated SBR value was overestimated as brain atrophy progressed, and a similar trend was observed when the ratios of the striatal to background region accumulation were changed. This study thus suggests that the SBR can be overestimated in cases of advanced brain atrophy.

摘要

特定结合比（SBR）是 N-ω-氟丙基-2β-羧甲基-3β-[4-[123I]碘苯基]去甲托烷([I]FP-CIT)单光子发射计算机断层扫描（SPECT）的客观指标，可用于帕金森病和路易体痴呆的诊断。SBR 分析存在的一个问题是，感兴趣区（VOI）的设置位置可能包含脑室内和脑沟。这些区域在脑萎缩分析中可能会变得突出；然而，这种现象尚未得到充分评估。本研究使用蒙特卡罗模拟来研究脑萎缩对 SBR 分析的影响。使用形态操作制作了用于模拟脑萎缩三个阶段的脑萎缩模型（BAM）。脑萎缩程度定义为 1 到 3 级，3 级表示最严重的损伤。根据 BAM 创建投影数据，并进行 SPECT 重建。将纹状体与背景区域的累积比设置为 8:1、6:1 和 4:1。随着脑萎缩的进展，纹状体和参考 VOI 的平均值降低。此外，Bolt 的分析方法表明，参考 VOI 值比纹状体 VOI 值受脑萎缩的影响更大。最后，随着脑萎缩的进展，计算出的 SBR 值被高估，并且当纹状体与背景区域的累积比发生变化时，也观察到类似的趋势。因此，本研究表明，在严重脑萎缩的情况下，SBR 值可能会被高估。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2eff/8742003/80e122006b44/41598_2021_4078_Fig8_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2eff/8742003/0c4c6739044b/41598_2021_4078_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2eff/8742003/90e393ac4d64/41598_2021_4078_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2eff/8742003/c3e6a3f29f77/41598_2021_4078_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2eff/8742003/80e122006b44/41598_2021_4078_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2eff/8742003/0ffb530f4b45/41598_2021_4078_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2eff/8742003/3b351e0248fe/41598_2021_4078_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2eff/8742003/f84cc2c86557/41598_2021_4078_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2eff/8742003/a7eba58f999f/41598_2021_4078_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2eff/8742003/0c4c6739044b/41598_2021_4078_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2eff/8742003/90e393ac4d64/41598_2021_4078_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2eff/8742003/c3e6a3f29f77/41598_2021_4078_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2eff/8742003/80e122006b44/41598_2021_4078_Fig8_HTML.jpg

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