Department of Physiology and Cell Biology, The Ohio State University Wexner Medical Center, 460 W. 12th Ave, Columbus, OH, 43210, USA.
Diabetes and Metabolism Research Center, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Curr Obes Rep. 2022 Mar;11(1):1-9. doi: 10.1007/s13679-021-00465-7. Epub 2022 Jan 7.
This review highlights aspects of brown adipose tissue (BAT) communication with other organ systems and how BAT-to-tissue cross-talk could help elucidate future obesity treatments.
Until recently, research on BAT has focused mainly on its thermogenic activity. New research has identified an endocrine/paracrine function of BAT and determined that many BAT-derived molecules, termed "batokines," affect the physiology of a variety of organ systems and cell types. Batokines encompass a variety of signaling molecules including peptides, metabolites, lipids, or microRNAs. Recent studies have noted significant effects of batokines on physiology as it relates whole-body metabolism and cardiac function. This review will discuss batokines and other BAT processes that affect the liver, cardiovascular system, skeletal muscle, immune cells, and brown and white adipose tissue. Brown adipose tissue has a crucial secretory function that plays a key role in systemic physiology.
本篇综述强调了棕色脂肪组织（BAT）与其他器官系统之间的交流方式，以及 BAT 与组织的相互作用如何有助于阐明未来的肥胖治疗方法。
直到最近，对 BAT 的研究主要集中在其产热活性上。新的研究已经确定了 BAT 的内分泌/旁分泌功能，并确定许多被称为“BATOKINES”的 BAT 衍生分子会影响各种器官系统和细胞类型的生理学。BATOKINES 包含各种信号分子，包括肽、代谢物、脂质或 microRNAs。最近的研究注意到 BATOKINES 对与全身代谢和心脏功能相关的生理学有显著影响。本篇综述将讨论 BATOKINES 以及影响肝脏、心血管系统、骨骼肌、免疫细胞以及棕色和白色脂肪组织的其他 BAT 过程。棕色脂肪组织具有重要的分泌功能，在全身生理学中起着关键作用。
