Tian Yuan, Yan Yuxuan, Fu Jingyan
State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
Bioessays. 2022 Mar;44(3):e2100262. doi: 10.1002/bies.202100262. Epub 2022 Jan 7.
The centriole is a widely conserved organelle required for the assembly of centrosomes, cilia, and flagella. Its striking feature - the nine-fold symmetrical structure, was discovered over 70 years ago by transmission electron microscopy, and since elaborated mostly by cryo-electron microscopy and super-resolution microscopy. Here, we review the discoveries that led to the current understanding of how the nine-fold symmetrical structure is built. We focus on the recent findings of the centriole structure in high resolution, its assembly pathways, and its nine-fold distributed components. We propose a model that the assembly of the nine-fold symmetrical centriole depends on the concerted efforts of its core proteins. Also see the video abstract here: https://youtu.be/m4h_3II_WJo.
中心粒是一种广泛保守的细胞器，是中心体、纤毛和鞭毛组装所必需的。其显著特征——九重对称结构，是70多年前通过透射电子显微镜发现的，此后主要通过冷冻电子显微镜和超分辨率显微镜进行了详细研究。在这里，我们回顾了一系列发现，这些发现使我们对九重对称结构的构建方式有了当前的认识。我们重点关注了中心粒结构的高分辨率最新发现、其组装途径及其九重分布的组件。我们提出了一个模型，即九重对称中心粒的组装依赖于其核心蛋白的协同作用。另请在此处查看视频摘要：https://youtu.be/m4h_3II_WJo 。
