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小儿实体器官移植中的疫苗接种:免疫接种临床医生入门指南。

Vaccination in pediatric solid organ transplant: A primer for the immunizing clinician.

作者信息

Chen Justin K, Cheng Jennifer, Liverman Rochelle, Serluco Anastacia, Corbo Heather, Yildirim Inci

机构信息

Department of Pharmacy, New York-Presbyterian, Columbia University Irving Medical Center, New York, New York, USA.

Department of Pharmacy, Children's Healthcare of Atlanta, Atlanta, Georgia, USA.

出版信息

Clin Transplant. 2022 Mar;36(3):e14577. doi: 10.1111/ctr.14577. Epub 2022 Jan 18.

Abstract

Pediatric solid organ transplant (SOT) recipients are at a uniquely elevated risk for vaccine preventable illness (VPI) secondary to a multitude of factors including incomplete immunization at the time of transplant, inadequate response to vaccines with immunosuppression, waning antibody titers observed post-SOT, and uncertainty among providers on the correct immunization schedule to utilize post-SOT. Multiple guidelines are in existence from the Infectious Diseases Society of America and the American Society of Transplantation, which require use in adjunct with additional published references. We summarize the present state of SOT vaccine recommendations from relevant resources in tandem with the Centers for Disease Control and Prevention Advisory Committee on Immunization Practices guidance utilizing both routine and rapid catch-up schedules. The purpose of this all-inclusive review is to provide improved clarity on the most optimal pre- and post-transplant vaccine management within a one-stop-shop for the immunizing clinician.

摘要

小儿实体器官移植(SOT)受者因多种因素而面临疫苗可预防疾病(VPI)的独特高风险,这些因素包括移植时免疫接种不完全、免疫抑制状态下对疫苗的反应不足、SOT后观察到的抗体滴度下降以及提供者对SOT后正确免疫接种时间表的不确定性。美国传染病学会和美国移植学会制定了多项指南,这些指南需要与其他已发表的参考文献一起使用。我们结合疾病控制与预防中心免疫实践咨询委员会的指导意见,利用常规和快速补种时间表,总结了相关资源中SOT疫苗建议的现状。这一全面综述的目的是为免疫接种临床医生提供一站式服务,以更清晰地了解移植前后最优化的疫苗管理。

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