Shan Xinying, Wei Conghui, Liu Shaowen, Luo Jun
School of Biological Science and Medical Engineering, Beihang University, 100191 Beijing, China.
Beijing Key Laboratory of Rehabilitation Technical Aids for Old-Age Disability, National Research Center for Rehabilitation Technical Aids, 100176 Beijing, China.
J Integr Neurosci. 2021 Dec 30;20(4):993-999. doi: 10.31083/j.jin2004100.
Previous studies have revealed significant changes in electroencephalogram (EEG) microstates in neuropsychiatric diseases, including schizophrenia, depression, and dementia. To explore the resting-state EEG microstate with amputation, we collected the EEG datasets from 15 patients with lower limb amputation and 20 healthy controls. Then, we analyzed the parameters of four classical EEG microstates (A-D) between the two groups. Specifically, the parameters were statistically analyzed, including duration, occurrence rate, time coverage, and transition rate. According to the results, the duration of microstate C (t = 2.95, p = 0.005) in the lower limb amputation group was significantly smaller compared with the control group, while the occurrence rate of microstate B (t = -2.22, p = 0.03) and D (t = -3.35, p = 0.002) were significantly larger in the lower limb amputation group. In addition, the transition rate of microstate differed significantly in AC, CA, DB between the two groups. Our results implied: (1) amputation has changed the resting-state EEG microstate; (2) EEG microstate analysis can be an approach to explore the alteration of cortical function.
先前的研究已经揭示了神经精神疾病（包括精神分裂症、抑郁症和痴呆症）中脑电图（EEG）微状态的显著变化。为了探究截肢后的静息态EEG微状态，我们收集了15名下肢截肢患者和20名健康对照者的EEG数据集。然后，我们分析了两组之间四种经典EEG微状态（A-D）的参数。具体而言，对这些参数进行了统计分析，包括持续时间、发生率、时间覆盖率和转换率。结果显示，与对照组相比，下肢截肢组中微状态C的持续时间（t = 2.95，p = 0.005）显著缩短，而微状态B（t = -2.22，p = 0.03）和D（t = -3.35，p = 0.002）的发生率在下肢截肢组中显著更高。此外，两组之间微状态在AC、CA、DB之间的转换率存在显著差异。我们的结果表明：（1）截肢改变了静息态EEG微状态；（2）EEG微状态分析可以作为一种探索皮质功能改变的方法。
