Nanbancha Ampika, Limroongreungrat Weerawat, Samala Manunchaya, Rattanakoch Jutima, Guerra Gary, Niamsang Wisavaporn, Tharawadeepimuk Kittichai
College of Sports Science and Technology, Mahidol University, Nakhon Pathom, 73170, Thailand.
Sirindhorn School of Prosthetics and Orthotics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand.
J Neuroeng Rehabil. 2025 Mar 26;22(1):68. doi: 10.1186/s12984-025-01606-y.
Individuals with lower-limb amputations are highly dependent upon prostheses to perform daily activities and adapt to environmental changes. Transtibial prosthesis (TTP) users in particular, experience greater challenges in motor control and demonstrate impaired cognitive functions, when compared to able-bodied persons. The identification of neural mechanisms underlying adaptation or compensation may contribute to the development and expansion of rehabilitation strategies.
To examine neuroplasticity changes in transtibial amputees by analyzing event-related potentials (ERPs) obtained from Electroencephalogram (EEG) during Go/No-Go tasks to assess cognitive control and neural adaptations.
Twenty-eight TTP users and twenty-eight able-bodied persons were recruited. EEG was recorded in eyes-open resting states, and ERPs during a Go/No-go task.
Our findings demonstrate that, during the resting-state, the TTP users group exhibited no significant differences in brain activity across regions. However, during Go/No-go task, an increase of N2 amplitude was observed, and significant reduction in the amplitude of P3 amplitude was noted when compared to able-bodied group.
These findings demonstrated neural modifications by individuals with transtibial amputation, particularly in relation to inhibitory control, which is essential for effective attentional control. Deficits in inhibitory control may interfere with decision-making processes, thereby impairing the execution of daily activities that require sustained attention and cognitive flexibility. Based on these findings of neural adaptions, it may be necessary to consider targeted interventions aimed at enhancing cognitive control and incorporating specific cortical training strategies for TTP users.
下肢截肢者在很大程度上依赖假肢来进行日常活动并适应环境变化。与身体健全的人相比，尤其是经胫截肢者（TTP）在运动控制方面面临更大挑战，且表现出认知功能受损。识别适应或补偿背后的神经机制可能有助于康复策略的发展和扩展。
通过分析在“是/否”任务期间从脑电图（EEG）获得的事件相关电位（ERP），以评估认知控制和神经适应性，来研究经胫截肢者的神经可塑性变化。
招募了28名TTP使用者和28名身体健全的人。在睁眼休息状态下记录脑电图，并在“是/否”任务期间记录ERP。
我们的研究结果表明，在静息状态下，TTP使用者组各区域的大脑活动没有显著差异。然而，在“是/否”任务期间，与身体健全组相比，观察到N2波幅增加，P3波幅显著降低。
这些发现表明经胫截肢者存在神经改变，特别是在抑制控制方面，这对于有效的注意力控制至关重要。抑制控制缺陷可能会干扰决策过程，从而损害需要持续注意力和认知灵活性的日常活动的执行。基于这些神经适应的发现，可能有必要考虑针对TTP使用者的旨在增强认知控制并纳入特定皮层训练策略的针对性干预措施。
