University of Tennessee College of Veterinary Medicine, Knoxville, TN 37996, USA.
University of Tennessee College of Veterinary Medicine, Knoxville, TN 37996, USA,
J Zoo Wildl Med. 2021 Dec;52(4):1229-1233. doi: 10.1638/2021-0004.
Infectious disease threats are increasingly recognized as a major contributor to mortality in wild populations of African wild dog ( AWD). Canine distemper virus (CDV) infection has been implicated as a cause of pack mortality in both captive and wild AWD populations. Ten animals were vaccinated with Recombitek C3, a vaccine containing a recombinant CDV, and modified live canine parvovirus (CPV) and adenovirus-2 components, at 8, 12, and 16 wk of age. Half of the pups received the vaccine IM and the other half SC. All ten pups had a positive serological response to CDV after the second vaccination, which decreased or stagnated after the third vaccination. Half of the pups had CDV titers ≥32 at 20 wk of age. Titers to CPV were high in all pups prior to vaccination and dropped precipitously over the course of the vaccine series. At the last sampling period, only 50% of the pups had measurable CPV titers. An initially higher titer was seen for CDV in the IM administration group; however, this was not significant at later time points. Vaccination with Recombitek C3 appears to be safe and effected a sustained serological response to CDV in AWD.
传染病威胁日益被认为是导致非洲野犬（AWD）野生种群死亡率上升的主要因素之一。犬瘟热病毒（CDV）感染已被认为是导致圈养和野生 AWD 种群死亡的原因之一。十只动物在 8、12 和 16 周龄时接种了 Recombitek C3，这是一种含有重组 CDV 以及改良的活犬细小病毒（CPV）和腺病毒-2 成分的疫苗。一半的幼犬通过肌肉注射（IM）和另一半通过皮下注射（SC）接受疫苗。在第二次接种后，所有十只幼犬都对 CDV 产生了阳性血清反应，第三次接种后反应下降或停滞。一半的幼犬在 20 周龄时的 CDV 滴度≥32。所有幼犬在接种疫苗前的 CPV 滴度都很高，在疫苗系列过程中急剧下降。在最后一次采样期间，只有 50%的幼犬可测量到 CPV 滴度。在肌肉注射组中，CDV 的初始滴度较高；然而，在以后的时间点，这并没有统计学意义。Recombitek C3 疫苗接种似乎是安全的，并在 AWD 中产生了对 CDV 的持续血清反应。
