β-内酰胺酶在耐甲氧西林金黄色葡萄球菌耐药性表达中的作用。
Role of beta-lactamase in expression of resistance by methicillin-resistant Staphylococcus aureus.
作者信息
Boyce J M, Medeiros A A
机构信息
Division of Infectious Diseases, Miriam Hospital, Providence, Rhode Island 02906.
出版信息
Antimicrob Agents Chemother. 1987 Sep;31(9):1426-8. doi: 10.1128/AAC.31.9.1426.
Abstract
Of 27 unique clinical isolates of methicillin-resistant Staphylococcus aureus, only 4 were homogeneously resistant, and all 4 produced little or no beta-lactamase. Among heterogeneously resistant strains, those most resistant to beta-lactam antibiotics produced the most beta-lactamase. Similar genes may regulate production of the low-affinity penicillin-binding protein and beta-lactamase.
摘要
在27株独特的耐甲氧西林金黄色葡萄球菌临床分离株中，只有4株是均一耐药的，并且这4株均产生很少的β-内酰胺酶或不产生β-内酰胺酶。在异质性耐药菌株中，那些对β-内酰胺类抗生素耐药性最强的菌株产生的β-内酰胺酶最多。相似的基因可能调控低亲和力青霉素结合蛋白和β-内酰胺酶的产生。
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