β-内酰胺酶在葡萄球菌对耐青霉素酶青霉素和头孢菌素耐药性中的作用。
The role of beta-lactamase in staphylococcal resistance to penicillinase-resistant penicillins and cephalosporins.
作者信息
McDougal L K, Thornsberry C
出版信息
J Clin Microbiol. 1986 May;23(5):832-9. doi: 10.1128/jcm.23.5.832-839.1986.
Abstract
We showed that most Staphylococcus aureus strains that have borderline or intermediate susceptibility to the penicillinase-resistant penicillins (PRPs) react this way because of the activity of their beta-lactamase on these antimicrobial agents. These strains produced large amounts of staphylococcal beta-lactamase that rapidly hydrolyzed penicillin and partially hydrolyzed the PRPs. Susceptibility to hydrolysis was penicillin greater than oxacillin greater than cephalothin greater than methicillin. The borderline results and the hydrolysis could be prevented by the beta-lactamase inhibitors clavulanic acid and sulbactam. For intrinsically methicillin-resistant (heteroresistant) S. aureus, the inhibitors reduced the penicillin MICs, but the strains remained resistant to all the beta-lactam antimicrobial agents, including penicillin. We conclude that the borderline in vitro susceptibility or resistance to PRPs in most of these S. aureus strains is mediated by beta-lactamase and they are not heteroresistant or intrinsically resistant. We do not know whether this in vitro resistance is expressed clinically.
摘要
我们发现，大多数对耐青霉素酶青霉素（PRPs）具有临界或中度敏感性的金黄色葡萄球菌菌株之所以有这种反应，是因为其β-内酰胺酶对这些抗菌药物有活性。这些菌株产生大量葡萄球菌β-内酰胺酶，能迅速水解青霉素并部分水解PRPs。对水解的敏感性顺序为青霉素大于苯唑西林大于头孢噻吩大于甲氧西林。β-内酰胺酶抑制剂克拉维酸和舒巴坦可防止临界结果和水解现象。对于固有耐甲氧西林（异质性耐药）的金黄色葡萄球菌，抑制剂降低了青霉素的最低抑菌浓度（MIC），但这些菌株对所有β-内酰胺类抗菌药物（包括青霉素）仍具有耐药性。我们得出结论，大多数这些金黄色葡萄球菌菌株对PRPs的体外临界敏感性或耐药性是由β-内酰胺酶介导的，它们并非异质性耐药或固有耐药。我们尚不清楚这种体外耐药性在临床上是否会表现出来。
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本文引用的文献
1
Liberation of surface-located penicillinase from Staphylococcus aureus.从金黄色葡萄球菌中释放表面定位青霉素酶。
Biochem J. 1967 Mar;102(3):742-7. doi: 10.1042/bj1020742.
2
NATURE AND INTERACTIONS OF THE GENETIC ELEMENTS GOVERNING PENICILLINASE SYNTHESIS IN STAPHYLOCOCCUS AUREUS.金黄色葡萄球菌中控制青霉素酶合成的遗传元件的性质及相互作用
J Bacteriol. 1965 Aug;90(2):467-80. doi: 10.1128/jb.90.2.467-480.1965.
3
PURIFICATION AND PROPERTIES OF THE EXOPENICILLINASE FROM STAPHYLOCOCCUS AUREUS.金黄色葡萄球菌外青霉素酶的纯化及性质
Biochem J. 1963 Sep;88(3):452-9. doi: 10.1042/bj0880452.
4
Inactivation of benzylpenicillin and methicillin by hospital staphylococci.医院葡萄球菌对苄青霉素和甲氧西林的灭活作用
Br Med J. 1963 Jul 27;2(5351):202-5. doi: 10.1136/bmj.2.5351.202.
5
Stability of the isoxazolyl penicillins to staphylococcal beta-lactamase.
J Antimicrob Chemother. 1982 Mar;9(3):239-40. doi: 10.1093/jac/9.3.239.
6
Comparative stabilities of penicillins and cephalosporins to staphylococcal beta-lactamase and activities against Staphylococcus aureus.青霉素和头孢菌素对葡萄球菌β-内酰胺酶的相对稳定性及对金黄色葡萄球菌的活性
J Antimicrob Chemother. 1980 May;6(3):333-41. doi: 10.1093/jac/6.3.333.
7
Inoculum standardization in antimicrobial susceptibility testing: evaluation of overnight agar cultures and the Rapid Inoculum Standardization System.抗菌药物敏感性试验中的接种物标准化：过夜琼脂培养物和快速接种物标准化系统的评估
J Clin Microbiol. 1983 Mar;17(3):450-7. doi: 10.1128/jcm.17.3.450-457.1983.
8
Amoxicillin combined with clavulanic acid for the treatment of soft tissue infections in children.阿莫西林联合克拉维酸治疗儿童软组织感染。
Antimicrob Agents Chemother. 1983 Nov;24(5):679-81. doi: 10.1128/AAC.24.5.679.
9
Successful use of broth microdilution in susceptibility tests for methicillin-resistant (heteroresistant) staphylococci.肉汤微量稀释法在耐甲氧西林（异质性耐药）葡萄球菌药敏试验中的成功应用。
J Clin Microbiol. 1983 Nov;18(5):1084-91. doi: 10.1128/jcm.18.5.1084-1091.1983.
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Low-affinity penicillin-binding protein associated with beta-lactam resistance in Staphylococcus aureus.与金黄色葡萄球菌β-内酰胺耐药性相关的低亲和力青霉素结合蛋白。
J Bacteriol. 1984 May;158(2):513-6. doi: 10.1128/jb.158.2.513-516.1984.
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