Department of General Surgery, The Seventh Affiliated Hospital of Sun Yat-Sen University (ShenZhen), Shen Zhen, China.
Department of General Surgery, The Seventh Affiliated Hospital of Sun Yat-Sen University (ShenZhen), Shen Zhen, China.
Am J Med Sci. 2022 Jun;363(6):511-518. doi: 10.1016/j.amjms.2021.10.026. Epub 2022 Jan 6.
Endoscopic ultrasound (EUS) is widely used as a cost-effective method for detecting pancreatic neuroendocrine tumors (PNTs), but its diagnostic value is variable among published studies. This meta-analysis aimed to determine the diagnostic value of EUS for PNTs.
Three electronic databases, including PubMed, Embase, and the Cochrane Library, were searched for studies published up to July 2018. The summary sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and receiver operating characteristic (ROC) curve were calculated to evaluate the diagnostic value of EUS using the random-effects model.
Thirteen studies involving 609 patients were included in this meta-analysis. The summary sensitivity and specificity of EUS for detecting PNTs were 0.86 and 0.89, respectively. The PLR and NLR of EUS were 7.81 and 0.15, respectively. The DOR of EUS for diagnosing PNTs was 24.20. The area under the ROC was 0.90. Finally, the subgroup analyses indicated that publication year and percentage of males could introduce potential biases for the DOR of EUS.
This meta-analysis suggests that EUS has a relatively high diagnostic value for diagnosing PNTs.
内镜超声（EUS）是一种经济有效的方法，广泛用于检测胰腺神经内分泌肿瘤（PNTs），但在已发表的研究中，其诊断价值存在差异。本荟萃分析旨在确定 EUS 对 PNTs 的诊断价值。
检索了三个电子数据库，包括 PubMed、Embase 和 Cochrane Library，检索截至 2018 年 7 月的研究。使用随机效应模型计算汇总敏感性、特异性、阳性似然比（PLR）、阴性似然比（NLR）、诊断比值比（DOR）和受试者工作特征（ROC）曲线，以评估 EUS 的诊断价值。
本荟萃分析共纳入了 13 项涉及 609 名患者的研究。EUS 检测 PNTs 的汇总敏感性和特异性分别为 0.86 和 0.89。EUS 的 PLR 和 NLR 分别为 7.81 和 0.15。EUS 诊断 PNTs 的 DOR 为 24.20。ROC 曲线下面积为 0.90。最后，亚组分析表明，发表年份和男性比例可能会给 EUS 的 DOR 带来潜在的偏倚。
本荟萃分析表明，EUS 对 PNTs 的诊断具有较高的诊断价值。
