Ormerod L D, Edelstein M A, Schmidt G J, Juarez R S, Finegold S M, Smith R E
Department of Ophthalmology, University of Southern California, Los Angeles.
Arch Ophthalmol. 1987 Nov;105(11):1571-5. doi: 10.1001/archopht.1987.01060110117044.
Anaerobic bacteria are prevalent in conjunctival flora but have not been adequately investigated as possible causes of endophthalmitis. The mean oxidation-reduction potential (Eh) of the rabbit vitreous was found to be +25.1 mV, well within the limiting Eh value of many anaerobes. There was an oxygen pressure gradient in the vitreous ranging from 2.1 mm Hg immediately posterior to the lens to approximately 20 mm Hg adjacent to the medullary ray. Endophthalmitis was produced with pure cultures of Fusobacterium necrophorum, Propionibacterium acnes, and Peptostreptococcus magnus. Relatively small inoculates of F necrophorum caused severe, acute endophthalmitis with scleral perforation; P acnes and P magnus produced a self-limited endophthalmitis; and vitreoretinal fibrosis was a sequela of the Propionibacterium acnes infection.
厌氧细菌在结膜菌群中普遍存在，但作为眼内炎的可能病因尚未得到充分研究。发现兔玻璃体的平均氧化还原电位（Eh）为+25.1 mV，完全在许多厌氧菌的极限Eh值范围内。玻璃体中存在氧分压梯度，从晶状体后紧邻处的2.1 mmHg到靠近髓放线处约为20 mmHg。用坏死梭杆菌、痤疮丙酸杆菌和大消化链球菌的纯培养物引发了眼内炎。相对少量的坏死梭杆菌接种物可导致严重的急性眼内炎并伴有巩膜穿孔；痤疮丙酸杆菌和大消化链球菌引发了一种自限性眼内炎；玻璃体视网膜纤维化是痤疮丙酸杆菌感染的后遗症。
