Ormerod D, Koh K, Juarez R S, Edelstein M A, Rife L L, Finegold S M, Smith R E
Invest Ophthalmol Vis Sci. 1986 Jan;27(1):115-8.
Anaerobic bacterial endophthalmitis was studied in rabbits following intravitreal injection of live Fusobacterium necrophorum. Clinical response, bacterial recovery, and histopathology were studied. An inoculum of approximately 50 organisms produced endophthalmitis in 59% of injected eyes, while 1000 or more organisms produced endophthalmitis in 100% of injected eyes. The course and severity of disease seemed to be independent of the concentration of bacteria above a minimal inoculum size. Affected eyes showed progressive endophthalmitis. Histopathologic changes corresponded to the clinical gradation of endophthalmitis, including progressive retinal necrosis.
通过向兔眼玻璃体内注射活的坏死梭杆菌来研究厌氧细菌性眼内炎。研究了临床反应、细菌回收情况及组织病理学。约50个菌的接种量使59%的注射眼发生眼内炎，而1000个或更多菌的接种量使100%的注射眼发生眼内炎。疾病的进程和严重程度似乎与高于最小接种量的细菌浓度无关。受影响的眼睛呈现进行性眼内炎。组织病理学变化与眼内炎的临床分级相对应，包括进行性视网膜坏死。
