Zanjan Pharmaceutical Biotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran.
Department of Chemistry, Hacettepe University, Beytepe, Ankara, 06800, Turkey.
Nanomedicine (Lond). 2022 Jan;17(2):95-105. doi: 10.2217/nnm-2021-0225. Epub 2022 Jan 10.
To prepare a novel hybrid system for the controlled release and delivery of curcumin (CUR). A method for the ultrasound-assisted fabrication of protein-modified nanosized graphene oxide-like carbon-based nanoparticles (CBNPs) was developed. After being modified with bovine serum albumin (BSA), CUR was loaded onto the synthesized hybrid (labeled CBNPs@BSA-CUR). The structure and properties of the synthesized nanoparticles were elucidated using transmission electron microscopy (TEM), atomic force microscopy (AFM), ultraviolet-visible spectroscopy (UV-Vis), Fourier-transform infrared spectroscopy (FTIR) and x-ray photoelectron spectroscopy (XPS) methods. CBNPs@BSA-CUR showed pH sensitivity and were calculated as controlled CUR release behavior. The drug-free system exhibited good biocompatibility and was nontoxic. However, CBNPs@BSA-CUR showed acceptable antiproliferative ability against MCF-7 breast cancer cells. CBNPs@BSA-CUR could be considered a highly promising nontoxic nanocarrier for the delivery of CUR with good biosafety.
为了制备一种用于姜黄素（CUR）控制释放和递送的新型混合系统。开发了一种超声辅助制备蛋白质修饰的纳米氧化石墨烯样碳基纳米粒子（CBNPs）的方法。在经过牛血清白蛋白（BSA）修饰后，将 CUR 加载到合成的混合体（标记为 CBNPs@BSA-CUR）上。使用透射电子显微镜（TEM）、原子力显微镜（AFM）、紫外-可见光谱（UV-Vis）、傅里叶变换红外光谱（FTIR）和 X 射线光电子能谱（XPS）方法阐明了合成纳米粒子的结构和性质。CBNPs@BSA-CUR 表现出 pH 敏感性，并被计算为控制 CUR 释放行为。无药物系统表现出良好的生物相容性且无毒。然而，CBNPs@BSA-CUR 对 MCF-7 乳腺癌细胞表现出可接受的抗增殖能力。CBNPs@BSA-CUR 可以被认为是一种具有良好生物安全性的用于递送 CUR 的有前途的无毒纳米载体。
