Division of Animal Science, Chonnam National University, Gwangju 61186, Republic of Korea.
J Microbiol Biotechnol. 2022 Mar 28;32(3):348-354. doi: 10.4014/jmb.2109.09054.
Recent studies have shown that probiotics have health-promoting effects, particularly intestinal immune modulation. In this study, we focused on the immunomodulatory properties of BYB3, formerly called , isolated from kimchi. In a mouse model of 14-day dextran sulfate sodium (DSS)-induced colitis, treatment with BYB3 significantly decreased the disease activity index, colon length, and weight loss. Moreover, histological analyses showed that BYB3 protected the structural integrity of the intestinal epithelial layer and mucin-secreting goblet cells from DSS-induced damage, with only slight infiltration by immune cells. To evaluate the molecular mechanisms underlying BYB3-driven inhibition of interleukin 6 production, possible in vivo anti-inflammatory effects of BYB3 were examined in the same mouse model. In addition, significantly lower levels of IL-6 and tumor necrosis factor receptor 1 upregulation were seen in the DSS+BYB3 group (compared to that in the DSS group). These results indicate that BYB3 exhibits health-promoting effects via immune modulation; and therefore, it can be used to treat various inflammatory diseases.
最近的研究表明，益生菌具有促进健康的作用，特别是对肠道免疫的调节。在这项研究中，我们专注于从泡菜中分离出的以前称为 BYB3 的免疫调节特性。在为期 14 天的葡聚糖硫酸钠（DSS）诱导的结肠炎的小鼠模型中，用 BYB3 治疗可显著降低疾病活动指数、结肠长度和体重减轻。此外，组织学分析表明，BYB3 保护了肠道上皮层和粘蛋白分泌的杯状细胞的结构完整性，免受 DSS 诱导的损伤，只有少量免疫细胞浸润。为了评估 BYB3 驱动的白细胞介素 6 产生抑制的分子机制，在相同的小鼠模型中检查了 BYB3 的可能的体内抗炎作用。此外，在 DSS+BYB3 组中观察到 IL-6 和肿瘤坏死因子受体 1 的上调水平明显降低（与 DSS 组相比）。这些结果表明，BYB3 通过免疫调节表现出促进健康的作用；因此，它可用于治疗各种炎症性疾病。
