Colden and Seymour Ear, Nose, Throat, and Allergy, Newburyport, MA, USA.
Anna Jaques Hospital, Newburyport, MA, USA.
Ear Nose Throat J. 2024 Sep;103(9):538-542. doi: 10.1177/01455613211070897. Epub 2022 Jan 9.
Plasmablastic lymphoma (PBL) is an aggressive, rare variant of B-cell lymphoma typically associated with human immunodeficiency virus and other immunocompromised populations. Most commonly found in the oral cavity, PBL can occasionally originate in the sinonasal tract. Diagnosis of PBL is difficult due to overlapping features with other malignancies; however, early detection and treatment are imperative given its aggressive clinical course. When in the sinonasal tract, the diagnostic process can be further complicated if the patient has a history of recurrent nasal polyposis. Described is the case of a 57-year-old immunocompetent male who initially presented with benign nasal polyposis, only to return a year after sinus surgery with a unilateral sinonasal mass consistent with PBL. As literature has yet to characterize this phenomenon, this article presents the first case reported of sinonasal PBL arising in the setting of recurrent nasal polyposis. This case emphasizes the importance of investigating sinonasal masses showing laterality, maintaining a high index of suspicion for malignancy, and keeping close surveillance of the patient after treatment of PBL.
浆母细胞淋巴瘤（PBL）是一种侵袭性的、罕见的 B 细胞淋巴瘤，通常与人类免疫缺陷病毒和其他免疫功能低下的人群相关。它最常见于口腔，但偶尔也可起源于鼻窦。由于其与其他恶性肿瘤具有重叠特征，因此 PBL 的诊断较为困难；然而，鉴于其侵袭性的临床病程，早期检测和治疗至关重要。如果患者有复发性鼻息肉的病史，那么在鼻窦中，诊断过程可能会更加复杂。本文介绍了一例 57 岁免疫功能正常的男性患者，最初表现为良性鼻息肉，仅在鼻窦手术后一年，出现单侧鼻窦肿块，符合 PBL。由于文献尚未对这种现象进行描述，因此本文报道了首例复发性鼻息肉背景下发生的鼻窦 PBL。该病例强调了对显示偏侧性的鼻窦肿块进行调查、对恶性肿瘤保持高度怀疑、以及在 PBL 治疗后对患者进行密切监测的重要性。
