Section of Dermatology, Department of Health Sciences, University of Florence, Florence, Italy.
Dermatology Unit, Versilia Hospital, USL Toscana Nord-Ovest, Lido di Camaiore, Lucca, Italy.
Int J Immunopathol Pharmacol. 2022 Jan-Dec;36:20587384211021218. doi: 10.1177/20587384211021218.
Linear IgA bullous dermatosis (LABD) is a mucocutaneous autoimmune blistering disease affecting both adults and children. It is caused by IgA antibodies targeting multiple antigens along the basement membrane zone, leading to disruption of dermoepidermal junction and development of bullous lesions which often presents in characteristic arrangement. Although most LABD cases have been reported to be idiopathic, different triggers have been described, including several drugs and infection. However, the occurrence of vaccine-induced cases of LABD is not widely known and accepted due to the few reports available. We present two cases of LABD occurred following different triggers, rising the suspicion for a possible pathogenetic role of vaccines.
线性 IgA 大疱性皮病（LABD）是一种影响成人和儿童的黏膜皮肤自身免疫性大疱性疾病。它是由 IgA 抗体针对基底膜带中的多种抗原引起的，导致表皮与真皮连接处的破坏和大疱性病变的发展，这些病变通常呈特征性排列。尽管大多数 LABD 病例被报道为特发性的，但已经描述了不同的触发因素，包括几种药物和感染。然而，由于报道较少，疫苗引起的 LABD 病例的发生并不广为人知和接受。我们报告了两例不同诱因引起的 LABD 病例，这引起了对疫苗可能具有致病作用的怀疑。
